TABLE 3.

Proportional use^a of chimeric CCR5:CXCR4 chemokine coreceptors by ADA-1 envelope mutants

Mutation or mutation combination	5555	5554	5545	5455	4555	4444
0	100
1	100
2	100
3	100
4	100
5	98.16		1.84
6	100
7	100
1, 2	100
1, 3	100
1, 4	90.46	1.60	3.48		1.92	2.54
1, 5	99.77				0.23
1, 6	100
1, 7	100
2, 4	91.39		0.82		3.51	4.29
3, 4	100
3, 5
3, 6	100
3, 7	100
4, 5	100
4, 6
5, 6	100
5, 7	55.22	2.23	24.57		6.80	11.19
6, 7	98.14		0.92		0.94
1, 2, 5	90.85	0.32	2.70		5.05	1.09
1, 3, 5			61.22		8.30	30.48
1, 4, 5	16.25	5.19	40.09		17.64	20.84
1, 5, 6	98.80				1.20
1, 5, 7	28.97	3.31	36.67	1.56	16.78	12.70
2, 4, 5	29.74	3.16	26.99		17.62	22.48
2, 5, 7	36.34	3.24	23.21	0.55	17.70	18.96
3, 4, 5			100
3, 4, 6
3, 4, 7			22.21			77.79
3, 5, 6
3, 6, 7	100
4, 5, 6
4, 5, 7		4.98	38.03		27.10	29.89
4, 6, 7	85.09		7.94		0.98	5.99
5, 6, 7	57.91		38.03		4.06
3, 4, 5, 6
3, 4, 5, 7
3, 4, 6, 7
3, 5, 6, 7
4, 5, 6, 7						100
3, 4, 5, 6, 7
1, 3, 4, 5, 6		4.46	41.19	0.88	19.80	33.67
1, 3, 4, 6, 7		3.71	37.90		25.33	33.05
1, 4, 5, 6, 7		2.20	39.53		29.45	28.82
1, 3, 4, 5, 6, 7			39.74			60.26
2, 3, 4, 5, 6, 7
1, 2, 3, 4, 5, 6, 7			48.16		42.53	9.31

^aNumbers represent the percentage of total infection mediated by one chemokine receptor compared to infection mediated by all coreceptors. Mutations are numbered as described in Table 1.