TABLE 2.
Test of MF for scrapie prophylaxis in Tg7 mice inoculated on day 0 with 50 μl of 1% 263K brain homogenatea
| Treatment | Dosing regimen | Survival times (days) | Mean survival time ± SD |
|---|---|---|---|
| None | 73, 76, 77, 79, 79, 88, 88, 89 | 81.1 ± 6.3 | |
| 5 mg/kg MFb | Days −2, −1, and 0 and then 3/wk for 4 wk | 74, 75, 80, 81, 88, 88, 89, 92 | 83.4 ± 6.8 |
a
The Rocky Mountain Laboratories Animal Care and Use Committee approved this procedure.
b
In 10% dimethyl sulfoxide-phosphate-buffered saline; a single i.p. dose at 50 mg/kg was not tolerated.