TABLE 1.
Subjects, laboratory studies, and clinical history
| Subject, sex, and date of Birtha | Date transfuseda | Date of blood samplea | Yr since infection | CD4+ T-cell count (cells/μl)b | Viral load (RNA copies/ml)c | Antiretroviral drugsd | Clinical historye |
|---|---|---|---|---|---|---|---|
| D36, male, 6/4/1958 | Not applicable; infected with HIV-1 via sexual transmission 12/1980 (18) | 2/1996 | 15.2 | 609 | 1,100 | ABC, AZT, NVP (1/1999-9/2004) (4, 5); ABC, NVP, 3TC (9/2004-present) | SP; diagnosed with HIVD 12/1998 (4) |
| 4/1996 | 15.3 | 504 | 7,800 | ||||
| 10/1997 | 16.8 | 336 | 4,400 | ||||
| 1/1999 | 18.1 | 210 | 9,900 | ||||
| 9/2000 | 19.8 | 391 | BD | ||||
| 4/2001 | 20.3 | 476 | BD | ||||
| 2/2003 | 22.2 | 624 | BD | ||||
| 2/2004 | 23.2 | 638 | BD | ||||
| C49, female, 6/9/1954 | 6/11/1984 | 2/1994 | 9.7 | 1,045 | BD | None | LTNP; diagnosed with age-onset diabetes in 2004, managed by diet; chronic alcoholism |
| 5/1994 | 9.8 | 1,458 | BD | ||||
| 10/1996 | 12.1 | 1,134 | BD | ||||
| 12/1997 | 13.5 | 918 | BD | ||||
| 6/1999 | 15.0 | 605 | BD | ||||
| 11/2001 | 17.4 | 624 | BD | ||||
| 8/2002 | 18.2 | 468 | BD | ||||
| 3/2004 | 19.7 | 874 | BD | ||||
| C54, male, 2/17/1928 | 7/24/1984 | 7/1993 | 9.0 | 1,519 | N/A | None | LTNP; IDDM; surgery for colon cancer in 1995; died 8/28/2001 from myocardial infarct; death not related to HIV-1 |
| 6/1995 | 10.9 | 1,504 | 3,000 | ||||
| 3/1996 | 11.7 | 1,188 | 1,500 | ||||
| 9/1996 | 12.2 | 1,120 | 1,800 | ||||
| 5/1997 | 12.8 | 1,286 | 5,500 | ||||
| 8/1997 | 13.1 | 1,419 | 1,700 | ||||
| 3/2000 | 15.7 | 840 | 1,600 | ||||
| 5/2001 | 16.8 | 1,537 | 2,660 | ||||
| C64, female, 3/20/1926 | 5/4/1983 | 8/1996 | 13.3 | 925 | BD | None | LTNP; hypertension; hypercholesterolemia |
| 2/1997 | 13.8 | 851 | BD | ||||
| 5/1997 | 14.0 | 1,050 | BD | ||||
| 8/1997 | 14.3 | 805 | BD | ||||
| 11/1997 | 14.5 | 936 | BD | ||||
| 4/1999 | 15.9 | 1,026 | BD | ||||
| 11/1999 | 16.5 | 1,332 | BD | ||||
| 5/2000 | 17.0 | 875 | BD | ||||
| C98, male, 7/11/1937 | 1/2/1982 | 7/1993 | 11.5 | 880 | N/A | d4T, NVP, IND (11/1999-death) | SP; prednisone since 1995 for asthma; died 3/30/2001 from bronchial amyloidosis; death not related to HIV-1 |
| 10/1995 | 13.8 | 576 | 670 | ||||
| 11/1996 | 14.8 | 646 | 690 | ||||
| 5/1997 | 15.3 | 527 | 760 | ||||
| 2/1998 | 16.1 | 627 | 1,100 | ||||
| 10/1998 | 16.8 | 429 | 1,500 | ||||
| 3/2000 | 18.2 | 684 | BD | ||||
| 3/2001 | 19.6 | 324 | BD |
Dates shown are month/day/year. The dates refer to times when PBMC were collected for HIV-1 nef/LTR sequencing. The results of only those laboratory studies that correspond to these time points are shown.
CD4+ T-cell levels were measured by flow cytometry.
Plasma HIV-1 RNA was measured using COBAS AMPLICOR HIV-1 monitor version 1.0 (Roche Molecular Diagnostic Systems, Branchburg, N.J.) prior to July 1999 and version 1.5 after July 1999. HIV-1 RNA levels of <400 copies/ml (version 1) or <50 copies/ml (version 1.5) were considered below detection. BD, below detection; N/A, not available.
ABC, abacavir; AZT, zidovudine; NVP, nevirapine; 3TC, lamivudine; d4T, stavudine; IND, indinavir.
HIVD, HIV-associated dementia; IDDM, insulin-dependent diabetes melitis.