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. 2026 Jul 30;16:1869639. doi: 10.3389/fonc.2026.1869639

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Copyright © 2026 Maghrebi, Mucignat, Lakhdar, Benhniya, Di Paolo, Etahiri, Capolongo, Pauletto, Giantin and Dacasto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Two clustered bubble plots compare biological process enrichment. Each plot displays GeneRatio on the x-axis and biological process descriptions on the y-axis. Bubble sizes represent gene counts, and color intensity indicates adjusted p-values. Processes such as response to external stimulus and lipid metabolic process are highly enriched. Both plots share similar patterns and annotation styles, with a color scale for p-values and a legend for count. — RNA-seq analysis. (A) Number of up- and downregulated DEGs obtained comparing PCE17 vs. CTRL and PCE33 vs. CTRL. (B) Venn diagram of the shared DEGs in PCE17 vs. CTRL and PCE33 vs. CTRL comparisons. CTRL, control; DEGs, differentially expressed genes; PCE17, Plocamium cartilagineum extract, 16.66 μg/mL; PCE33, Plocamium cartilagineum extract, 33.32 μg/mL.