FIG. 5.

ADAR2 autoediting is a key regulator of ADAR2 protein levels. Correlation between ADAR2 autoediting levels in isolated tissues from wild-type mice (from Fig. 3) and relative increases in ADAR2 protein expression from the corresponding tissues in ΔECS animals (from Fig. 4) was determined by nonlinear regression with the equation Y = A/(B − X) (A = 70; B = 98). The best-fit lines defined by the observed [Y = 70/(98−X)] and predicted [Y = 100/(100 − X)] data are indicated with solid and dashed lines, respectively.