FIG. 6.

Model of ADAR2 autoregulation. A schematic diagram of the biosynthetic processes involved in the production of ADAR2 is presented, showing a region of the ADAR2 pre-mRNA between exon 3 and 5, the predicted RNA duplex required for A-to-I editing, and the position of the −1 site (*). The RNA processing pathway lacking −1 site editing, leading to the production of full-length (711-amino-acid [aa]) ADAR2b is indicated with dashed arrows; the functional domains in ADAR2 (nuclear localization signal [NLS], dsRBD, and adenosine deaminase domain) are indicated. The biosynthetic pathway involving A-to-I conversion at the −1 site (*), leading to the production of a predicted 9-kDa (83-aa) protein, is indicated with solid arrows; the cross-hatched box represents the amino acid sequences encoded by an altered reading frame resulting from proximal 3′ splice acceptor use and inclusion of an additional 47 nt in the mature ADAR2 transcript.