TABLE 3.
Host defense response genes induced by reovirusa
| Class and gene symbol | GenBank accession no. | Avg fold increase
|
|||
|---|---|---|---|---|---|
| 0 h | 2 h | 6 h | 10 h | ||
| Kinetic class 1 | |||||
| CXCL1 | X54489 | 1.54 | 1.75 | 4.98 | 2.10 |
| CXCL2 | M36820 | 0.61 | 2.84 | 1.96 | 2.57 |
| IFITM3 | X57352 | 1.22 | 1.42 | 1.1 | 1.84 |
| IL4R | X52425 | 1.14 | 1.33 | 1.60 | 1.91 |
| IL6 | X04430 | 1.05 | 3.45 | 4.75 | 4.21 |
| IL8 | M28130 | 1.05 | 4.43 | 8.46 | 0.80 |
| NFKB1 | M58603 | 0.97 | 1.32 | 1.38 | 1.21 |
| Kinetic class 3 | |||||
| PSMB9 | AA808961 | 1.38 | 1.46 | 1.45 | 3.24 |
| BF | L15702 | 1.04 | 0.91 | 5.35 | 5.38 |
| CCL5 | M21121 | 1.04 | 0.91 | 3.92 | 3.07 |
| CXCL10 | X02530 | 1.05 | 0.91 | 0.91 | 2.93 |
| CXCL11 | AF030514 | 1.05 | 0.91 | 1.31 | 5.45 |
| G1P2 | AA203213 | 1.05 | 2.65 | 1.2 | 2.14 |
| G1P3 | U22970 | 1.05 | 0.91 | 0.98 | 3.11 |
| IFI16 | M63838 | 1.2 | 0.93 | 1.13 | 2.99 |
| IFIT1 | M24594 | 1.78 | 1.04 | 1.1 | 3.14 |
| IFIT2 | M14660 | 1.05 | 0.91 | 0.83 | 1.85 |
| IFIT5 | U34605 | 0.86 | 1.22 | 1.13 | 1.97 |
| IFITM1 | J04164 | 1.05 | 0.97 | 1.14 | 2.90 |
| IL15 | AF031167 | 0.87 | 0.95 | 1.29 | 2.12 |
| IRF1 | L05072 | 1.05 | 0.91 | 9.04 | 8.62 |
| IRF7 | U53831 | 1.05 | 0.91 | 0.98 | 3.44 |
| MX2 | M30818 | 1.05 | 0.91 | 0.98 | 3.15 |
| NMI | U32849 | 1.17 | 0.91 | 1.28 | 1.89 |
| OAS1 p40/46 | X04371 | 1.05 | 0.91 | 0.98 | 10.98 |
| OASL p59 | AJ225089 | 1.05 | 1.6 | 1.27 | 1.78 |
| PTGES | AF010316 | 5.6 | 12.02 | 1.35 | 1.08 |
| TAP1 | X57522 | 1.37 | 1.14 | 1.36 | 2.21 |
a
Shown is a subset of reovirus-responsive, NF-κB-dependent genes identified in the microarray analysis that are categorized as defense response by the DAVID program (14). Genes are listed alphabetically by kinetic class. Average fold change is expressed as a ratio of mRNA levels in uninduced cells (+doxycycline) divided by mRNA levels in induced cells (−doxycycline) at the indicated times after infection. Values less than 1 represent a decrease in expression.