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Ki values for foscarnet-mediated inhibition of DNA synthesisa
| Enzyme | Foscarnet
|
|
|---|---|---|
| Ki (μM)b | Fold resistancec | |
| WT | 0.30 ± 0.08 | 1 |
| L802M | 2.0 ± 0.4 | 6.7 |
| K805Q | 0.14 ± 0.03 | 0.47 |
| Q807A | 1.9 ± 0.7 | 6.3 |
As described in Materials and Methods.
Values are means of at least three independent determinations ± standard deviations.
Values of less than 1 represent hypersusceptibility.
