TABLE 3.

FG loop length correlations

Strain	Host	P typea	RRV Q135 equivalentb	SA dependencec	Residue at position 101	Genbank accession no.
SA11-4f	Simian	6[1]	Present	+	R	X57319
NCDV-Lin	Bovine	6[1]	Present	+h	R	M63267
RF	Bovine	6[1]	Present	+	R	U65924
BRV033	Bovine	6[1]	Present	+	R	U62155
SA11 cl3	Simian	5B[2]	Present	+h	R	M23188
RRV	Simian	5B[3]	Present	+h	R	AY033150
CU-1	Canine	5A[3]	Present	+	R	D13401
HCR3	Human	5A[3]	Present	+	R	L19712
K9	Canine	5A[3]	Present	+	R	D14725
Cat97	Feline	5A[3]	Present	+	R	D13402
DS-1	Human	1B[4]	Absent	−h	F	DQ141310
L26	Human	1B[4]	Absent	−	F	M58292
4S	Porcine	7[5]	Present	−	R	L10358
UK	Bovine	7[5]	Present	−d,h	R	M22306
WC3	Bovine	7[5]	Present	−	R	AY050271
B461	Bovine	7[5]	Present	−	R	M63267
678	Bovine	7[5]	Present	−	R	D32054
M37	Human	2A[6]	Absent	−	I	Nonee
1076	Human	2A[6]	Absent	−h	I	Nonee
McN13	Human	2A[6]	Absent	−	I	Nonee
ST3	Human	2A[6]	Absent	−	I	L33895
Gott	Porcine	2B[6]	Absent	−	V	M33516
CRW-8	Porcine	9[7]	Present	+	R	L07888
OSU	Porcine	9[7]	Present	+h	R	X13190
H1	Equine	9[7]	Present	+	R	D16341
TFR-41	Porcine	9[7]	Present	+	R	L07889
YM	Porcine	9[7]	Present	+	R	M63231
Wa	Human	1A[8]	Absent	−	F	M96825
KU	Human	1A[8]	Absent	−h	F	M21014
MO	Human	1A[8]	Absent	−	F	AB008278
YO	Human	1A[8]	Absent	−	F	AB008279
Ito	Human	1A[8]	Absent	−	F	AB008280
VA70	Human	1A[8]	Absent	−	F	AJ540229
Hochi	Human	1A[8]	Absent	−	F	AB039943
K8	Human	3[9]	Present	−h	R	D90260
O264	Human	3[9]	Present	−	R	AB008665
Cat2	Feline	3[9]	Present	−	R	D13403
69M	Human	4[10]	Present	−h	R	M60600
B233	Bovine	8[11]	Absent	−h	F	D13394
I321	Human	8[11]	Absent	−	F	L07657
H-2	Equine	4[12]	Present	−h	R	L04638
FI-14	Equine	4[12]	Present	−	R	D13398
FI23	Equine	4[12]	Present	−	R	D16342
A46	Porcine	[13]	Present	−h	M	AY070274
Ala	Lapine	11[14]	Present	−h	R	U62149
C-11	Lapine	11[14]	Present	−	R	U62150
BAP-2	Lapine	11[14]	Present	−	R	U62151
R-2	Lapine	11[14]	Present	−	R	U62152
PA169	Lapine	11[14]	Present	−	R	D14724
HAL1166	Human	11[14]	Present	−	R	L20885
Mc35	Human	11[14]	Present	−	R	D14032
Lp14	Ovine	[15]	Present	−h	R	L11599
EW	Murine	10[16]	Present	−	R	U08429
EC	Murine	10[16]	Present	+/−f	R	U08421
EB	Murine	10[16]	Present	−h	R	U08419
EDIM	Murine	10[16]	Present	−	R	AF039219
Ty-1	Avian	[17]	Present	−h	R	L41493
L338	Equine	12[18]	Present	+/−f	R	D13399
4F	Porcine	[19]	Absent	−h	V	L10359
EHP	Murine	[20]	Present	+/−g	R	U08424

^aP serotype[P genotype]. Some strains have not been serotyped. Many of the strain classifications were obtained from reference 6.

^bIndicates the presence or absence of a residue that is structurally equivalent to residue 135 of strain RRV.

^cSA dependence is based on published data that define SA independence as a preserved infectious titer on cultured cells or enterocytes digested with Arthrobacter ureafaciens neuraminidase (5, 6, 10, 31).

^dAlthough UK entry is not SA dependent, it binds glycosphingolipids with a specificity dependent upon the SA moiety in the oligosaccharide chain (10).

^eSequences from reference 17.

^fWeak inhibition by neuraminidase digestion of MA104 cells (6).

^gCell-type-specific neuraminidase sensitivity (31).

^hStrain included in the SA-dependent and SA-independent sets used to calculate variability for Table S1 in the supplemental material and Fig. 5A to C.