FIG. 1.
Sequence analysis of MVMp evolution in SCID mice. (Top) Amino acid substitutions in the VP gene of plaque-isolated MVMp clones obtained from main organs (B, brain; K, kidney; L, liver) of SCID mice (no. 1 to 5) sequenced across the entire VP gene (nt 2240 to 4687). (Bottom) Distribution of amino acid changes in the entire collection of MVMp clones. A VP region (nt 3710 to 4200) of the MVMp genome was sequenced in viral clones (n = 48) obtained from the indicated mice (no. 1 to 7) and organs. The amino acid changes at residues 325, 362, and 368 of the VP2 sequence are outlined. n, number of clones with identical genotypes in this region.