TABLE 6.

Nucleotide and amino acid differences between the sequences of the brain-adapted virus isolates and the sequence of virus used for i.p. inoculation of immunodeficient mice

^aVirus isolates (1 and 2) were derived from brains of two separate moribund mice as indicated in Table 4.

^bHis₁₃₀→Tyr amino acid substitution was previously found to be responsible for the increased neuroinvasiveness of LGT virus in immunodeficient mice (25).

^cA reversion to the sequence of parental E5 or wild-type LGT virus.

^dAmino acid substitutions that emerged in two or more virus isolates are indicated by dashed boxes.