FIG. 4.

Identification of cis-acting elements in Nm23-H1-induced COX-2 (−327/+59) firefly luciferase (Luc) reporter constructs containing wild-type CRE (−59/−53), NF-IL-6 (−132/−124), and NF-κB (−223/−214) cis-acting elements or their respective site-directed mutants. The results are expressed as the means ± SEMs (error bars) of three separate experiments performed in duplicate or triplicate. Constructs ILM, CRM, and KBM are described in Materials and Methods. Anti-Nm23-H1 (α-Nm23H1) antibody was used.