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. 2002 Nov;22(22):7842–7852. doi: 10.1128/MCB.22.22.7842-7852.2002

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FIG. 4. — FoxO-induced downregulation of cyclin D does not depend on induction of quiescence. MEFs deficient for pRb/p107/p130 pocket proteins (TKO) were infected with a FoxO3a.A3-containing retrovirus (FoxO3A3) or a control retrovirus (puro) (A and B) or treated with 10 μM LY294002 (LY) (A). (A) FACS analysis of BrdU incorporation 48 h after infection with the indicated retrovirus or 24 h after LY294002 treatment. (B) Expression levels of cyclin D1, cyclin D2, and HA-FoxO3a.A3 proteins in lysates prepared 48 h postinfection as determined by Western blotting. An immunoblot for CDK4 is shown as a control for equal loading.