Table 2.

MR estimates for the association of genetically predicted liability to cholecystectomy with ischemic stroke and its subtypes

Outcome	No. of SNPs	Method	P-value	OR (95% CI)
Primary outcome
Ischemic stroke	41	MR-Egger	0.104	0.33 (0.09–1.22)
		Weighted median	< 0.001	0.14 (0.05–0.37)
		IVW	0.208	0.57 (0.23–1.37)
Secondary outcomes
Small-vessel ischemic stroke	32	MR-Egger	0.383	0.31 (0.02–4.2)
		Weighted median	0.042	0.14 (0.02–0.93)
		IVW	0.009	0.10 (0.02–0.57)
Large-artery atherosclerotic ischemic stroke	39	MR-Egger	0.028	0.02 (0.001–0.58)
		Weighted median	< 0.001	0.01 (0.001–0.14)
		IVW	0.023	0.09 (0.01–0.71)
Cardioembolic ischemic stroke	41	MR-Egger	0.110	0.15 (0.02–1.45)
		Weighted median	0.054	0.15 (0.02–1.04)
		IVW	0.706	0.74 (0.16–3.47)

SNP single nucleotide polymorphism, OR odds ratio, IVW inverse-variance weighted, MR-Egger Mendelian randomization-Egger