Table 2.
Clinicopathologic characteristics of lymphoglandular complex-like carcinoma in 20 cases
| Characteristic | n (%) or Value |
| Demographics | |
| Age, mean ± SD (range) | 64.4 ± 13.7 (41-88) years |
| Female sex | 12 (60%) |
| Lesion characteristics | |
| Median size (range) | 1.1 (0.8-5.0) cm |
| Most common site | Ascending colon/cecum, 7 (35%) |
| Sessile appearance | 12/14 with data (86%) |
| Surface histology | |
| TA with high-grade dysplasia | 10 (50%) |
| TA without dysplasia | 6 (30%) |
| Sessile serrated lesion | 3 (15%) |
| Histologic features | |
| Germinal centers >50% of infiltrate | 15 (75%) |
| High-grade dysplasia in submucosa | 11 (55%) |
| Angulation | 18 (90%) |
| Fused glands | 15 (75%) |
| Luminal necrosis | 13 (65%) |
| Loss of polarity | 11 (55%) |
| Desmoplasia | 10 (50%) |
| Single-cell infiltration | 7 (35%) |
| Goblet cells | 2 (10%) |
| Pathologic stage | |
| T1 | 18 (90%) |
| T3 | 2 (10%) |
| Node-positive disease (among those with lymphadenectomy) | 4/11 (36%) |
| Molecular and outcome data | |
| MMR deficiency | 2/9 tested (22%) |
| Alive without disease at follow-up | 11/14 (79%) |
Adapted from Yilmaz et al7.
LGCC, lymphoglandular complex-like carcinoma; MMR, mismatch repair; TA, tubular adenoma.