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. 2006 Jan 12;103(4):1006–1011. doi: 10.1073/pnas.0506982103

Fig. 1.

Fig. 1.

The FXR agonist GW4064 regulates glucose and lipid homeostasis in an FXR-dependent manner. (A) Murine primary hepatocytes were treated with either vehicle (DMSO) or GW4064 (1 μM) for 24 h. mRNA levels were quantified by real-time PCR and normalized to cyclophilin. F1, 6Pase, fructose 1,6-bis phosphatase. (B–E) Wild-type and FXR–/– mice were gavaged with either vehicle (open bars) or GW4064 (filled bars) for 11 days (n = 6 per group). After a 6-h fast, livers were removed and hepatic mRNA levels were quantified by real-time PCR (B). Plasma glucose (C), triglyceride (D), and cholesterol (E) levels were determined after a 6-h fast. *, P < 0.05. **, P < 0.01 versus control (A and C–E) or vehicle-treated wild-type group (B), unless specifically indicated.