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. 2006 Jan 12;103(4):1006–1011. doi: 10.1073/pnas.0506982103

Fig. 4.

Fig. 4.

Hepatic expression of FXR-VP16 decreases plasma glucose and cholesterol levels in nondiabetic mice. (A–C) C57BL/6J mice were separately transfused with Ad-VP16 (VP16) or Ad-FXR-VP16 (FXR) or saline alone (WT) by tail vain injection (n = 8 per group). After 7 days, mice were fasted for 6 h before being killed. Hepatic mRNA levels were quantified by Northern blot assay (A), and plasma cholesterol (B) and glucose (C) levels were determined. (D) Hepatic expression of FXRα2-VP16 lowers plasma glucose levels in FXR–/– mice. FXR–/– mice were either separately transfused with the indicated adenovirus or saline alone (KO) by tail vain injection (n = 6 per group). After 7 days, mice were fasted for 16 h before being killed. Hepatic mRNA levels were determined by Northern blot assay (Inset), and plasma glucose levels were determined. *, P < 0.05. **, P < 0.01. #, P < 0.001 versus mice transfused with Ad-VP16.