Figure 2.

Joinpoint regression analysis of age-standardized ischemic stroke rates in China and the United States, 1990 to 2023. Joinpoint regression results showing (A) incidence, (B) prevalence, (C) mortality, and (D) DALYs of ischemic stroke for both sexes combined in China and the United States from 1990 to 2023. Each panel displays age-standardized rates per 100,000 population on a logarithmic scale with identified joinpoints (marked by circles) representing significant changes in temporal trends. Solid line segments indicate periods of statistically significant trends, with annual percent change values and 95% confidence intervals annotated for each segment. Vertical dashed lines denote joinpoint years. The analysis identifies distinct phases of trend changes, revealing heterogeneous temporal patterns within the study period. Average annual percent change (AAPC) for the entire period is provided for each country and measure. APC = annual percent change; AAPC = average annual percent change, DALYs = disability-adjusted life years.