Table 2.
Age-specific trends in ischemic stroke burden in China and the United States, 1990 to 2023.
| Location | Gender | Indicator | Age group | Cases in 1990 (n) | Cases in 2023 (n) | Change in cases (%) | Rate in 1990 (per 100,000) | Rate in 2023 (per 100,000) | Change in rate (%) | EAPC (95% CI) | AAPC (95% CI) | AAPC P-value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| China | Both | Incidence | 5 to 9 | 7126 | 5738 | -19.48 | 6.82 | 5.67 | −16.78 | −0.62 (−0.78 to −0.47) |
−0.56 (−0.60 to −0.51) | <.001 |
| China | Both | Incidence | 10 to 14 | 6317 | 5373 | −14.94 | 6.16 | 6.05 | −1.72 | −0.14 (−0.27 to −0.02) |
−0.10 (−0.13 to −0.07) | <.001 |
| China | Both | Incidence | 15 to 19 | 8041 | 5538 | −31.14 | 6.33 | 6.87 | 8.56 | 0.01 (−0.1 to 0.11) |
0.21 (0.14 to 0.26) | <.001 |
| China | Both | Incidence | 20 to 24 | 9542 | 6046 | −36.64 | 7.21 | 8.54 | 18.54 | 0.23 (0.12 to 0.34) |
0.47 (0.39 to 0.54) | <.001 |
| China | Both | Incidence | 25 to 29 | 9708 | 8578 | −11.65 | 8.81 | 11 | 24.81 | 0.47 (0.37 to 0.57) |
0.62 (0.52 to 0.70) | <.001 |
| China | Both | Incidence | 30 to 34 | 10,985 | 17,273 | 57.24 | 12.41 | 16.08 | 29.54 | 0.58 (0.48 to 0.68) |
0.72 (0.62 to 0.80) | <.001 |
| China | Both | Incidence | 35 to 39 | 16,341 | 27,981 | 71.23 | 17.85 | 23.67 | 32.62 | 0.58 (0.46 to 0.7) |
0.74 (0.68 to 0.80) | <.001 |
| China | Both | Incidence | 40 to 44 | 21,331 | 36,382 | 70.56 | 31.7 | 40 | 26.19 | 0.48 (0.33 to 0.63) |
0.68 (0.63 to 0.74) | <.001 |
| China | Both | Incidence | 45 to 49 | 27,960 | 65,322 | 133.63 | 54.02 | 65.49 | 21.23 | 0.44 (0.26 to 0.62) |
0.55 (0.49 to 0.62) | <.001 |
| China | Both | Incidence | 50 to 54 | 53,353 | 142,288 | 166.69 | 111.53 | 120.18 | 7.76 | 0.13 (−0.02 to 0.28) |
0.19 (0.14 to 0.24) | <.001 |
| China | Both | Incidence | 55 to 59 | 88,195 | 241,402 | 173.71 | 202.76 | 204.19 | 0.71 | −0.08 (−0.2 to 0.05) |
−0.01 (−0.06 to 0.04) | .547 |
| China | Both | Incidence | 60 to 64 | 119,961 | 269,620 | 124.76 | 338.37 | 331.11 | −2.15 | −0.19 (−0.32 to −0.07) |
−0.11 (−0.16 to −0.06) | <.001 |
| China | Both | Incidence | 65 to 69 | 141,731 | 379,287 | 167.61 | 517.05 | 497.02 | −3.88 | −0.28 (−0.41 to −0.15) |
−0.18 (−0.24 to −0.12) | <.001 |
| China | Both | Incidence | 70 to 74 | 134,794 | 444,988 | 230.13 | 714.08 | 728.83 | 2.07 | −0.02 (−0.19 to 0.15) |
0.02 (−0.04 to 0.08) | .407 |
| China | Both | Incidence | 75 to 79 | 106,194 | 377,921 | 255.88 | 929.34 | 1027.31 | 10.54 | 0.33 (0.11 to 0.55) |
0.26 (0.20 to 0.30) | <.001 |
| China | Both | Incidence | 80 to 84 | 66,212 | 298,042 | 350.13 | 1185.71 | 1326.73 | 11.89 | 0.34 (0.13 to 0.55) |
0.29 (0.25 to 0.33) | <.001 |
| China | Both | Incidence | 85 to 89 | 29,866 | 205,060 | 586.6 | 1496.24 | 1644.14 | 9.88 | 0.19 (0.02 to 0.37) |
0.27 (0.24 to 0.30) | <.001 |
| China | Both | Incidence | 90 to 94 | 6824 | 88,378 | 1195.1 | 1812.14 | 1951.61 | 7.7 | 0.08 (−0.06 to 0.23) |
0.21 (0.20 to 0.23) | <.001 |
| China | Both | Incidence | 95 plus | 1364 | 27,591 | 1923.22 | 2082.68 | 2222.23 | 6.7 | −0.05 (−0.19 to 0.09) |
0.18 (0.16 to 0.20) | <.001 |
| China | Both | Prevalence | 5 to 9 | 66,783 | 44,871 | −32.81 | 63.87 | 44.35 | −30.56 | −1.28 (−1.38 to −1.19) |
−1.13 (−1.16 to −1.10) | <.001 |
| China | Both | Prevalence | 10 to 14 | 99,933 | 65,798 | −34.16 | 97.44 | 74.12 | −23.93 | −0.97 (−1.05 to −0.9) |
−0.85 (−0.86 to −0.83) | <.001 |
| China | Both | Prevalence | 15 to 19 | 165,883 | 86,308 | −47.97 | 130.62 | 107.13 | −17.98 | −0.73 (−0.8 to −0.65) |
−0.61 (−0.63 to −0.60) | <.001 |
| China | Both | Prevalence | 20 to 24 | 220,412 | 101,442 | −53.98 | 166.51 | 143.37 | −13.9 | −0.55 (−0.6 to −0.5) |
−0.45 (−0.46 to −0.44) | <.001 |
| China | Both | Prevalence | 25 to 29 | 231,276 | 146,201 | −36.78 | 209.92 | 187.46 | −10.7 | −0.37 (−0.4 to −0.34) |
−0.34 (−0.35 to −0.34) | <.001 |
| China | Both | Prevalence | 30 to 34 | 234,002 | 269,891 | 15.34 | 264.41 | 251.25 | −4.98 | −0.15 (−0.18 to −0.13) |
−0.15 (−0.16 to −0.15) | <.001 |
| China | Both | Prevalence | 35 to 39 | 309,408 | 406,281 | 31.31 | 337.91 | 343.67 | 1.7 | 0.04 (0.03 to 0.06) |
0.05 (0.05 to 0.06) | <.001 |
| China | Both | Prevalence | 40 to 44 | 301,289 | 436,242 | 44.79 | 447.76 | 479.67 | 7.13 | 0.23 (0.2 to 0.25) |
0.22 (0.21 to 0.22) | <.001 |
| China | Both | Prevalence | 45 to 49 | 334,096 | 717,296 | 114.7 | 645.51 | 719.13 | 11.4 | 0.39 (0.35 to 0.43) |
0.33 (0.33 to 0.34) | <.001 |
| China | Both | Prevalence | 50 to 54 | 473,236 | 1,316,958 | 178.29 | 989.24 | 1112.32 | 12.44 | 0.48 (0.43 to 0.53) |
0.36 (0.35 to 0.37) | <.001 |
| China | Both | Prevalence | 55 to 59 | 696,547 | 2,117,992 | 204.07 | 1601.32 | 1791.53 | 11.88 | 0.48 (0.44 to 0.53) |
0.34 (0.33 to 0.34) | <.001 |
| China | Both | Prevalence | 60 to 64 | 893,165 | 2,298,153 | 157.3 | 2519.36 | 2822.3 | 12.02 | 0.46 (0.43 to 0.49) |
0.34 (0.33 to 0.35) | <.001 |
| China | Both | Prevalence | 65 to 69 | 1,063,330 | 3,266,407 | 207.19 | 3879.15 | 4280.28 | 10.34 | 0.36 (0.34 to 0.38) |
0.30 (0.29 to 0.30) | <.001 |
| China | Both | Prevalence | 70 to 74 | 1,021,479 | 3,638,928 | 256.24 | 5411.34 | 5960.08 | 10.14 | 0.35 (0.33 to 0.37) |
0.29 (0.28 to 0.29) | <.001 |
| China | Both | Prevalence | 75 to 79 | 752,759 | 2,779,503 | 269.24 | 6587.63 | 7555.55 | 14.69 | 0.53 (0.5 to 0.56) |
0.41 (0.40 to 0.42) | <.001 |
| China | Both | Prevalence | 80 to 84 | 392,833 | 1,946,182 | 395.42 | 7034.78 | 8663.38 | 23.15 | 0.81 (0.76 to 0.87) |
0.63 (0.61 to 0.64) | <.001 |
| China | Both | Prevalence | 85 to 89 | 128,356 | 1,100,885 | 757.68 | 6430.46 | 8826.72 | 37.26 | 1.21 (1.13 to 1.29) |
0.96 (0.95 to 0.97) | <.001 |
| China | Both | Prevalence | 90 to 94 | 21,326 | 381,879 | 1690.68 | 5663.19 | 8432.87 | 48.91 | 1.53 (1.43 to 1.64) |
1.21 (1.20 to 1.22) | <.001 |
| China | Both | Prevalence | 95 plus | 3313 | 97,595 | 2845.4 | 5060.33 | 7860.45 | 55.33 | 1.66 (1.55 to 1.78) |
1.34 (1.32 to 1.35) | <.001 |
| China | Both | Deaths | 5 to 9 | 94 | 19 | −79.85 | 0.09 | 0.02 | −79.18 | −4.52 (−5.22 to −3.81) |
−4.73 (−4.98 to −4.54) | <.001 |
| China | Both | Deaths | 10 to 14 | 76 | 22 | −70.83 | 0.07 | 0.02 | −66.3 | −3.11 (−3.61 to −2.6) |
−3.33 (−3.49 to −3.21) | <.001 |
| China | Both | Deaths | 15 to 19 | 372 | 68 | -81.85 | 0.29 | 0.08 | -71.39 | -3.59 (-3.74 to −3.43) |
-3.66 (-3.75 to −3.55) | <.001 |
| China | Both | Deaths | 20 to 24 | 691 | 86 | -87.55 | 0.52 | 0.12 | -76.71 | -4.65 (-4.95 to −4.35) |
-4.12 (-4.22 to −4.03) | <.001 |
| China | Both | Deaths | 25 to 29 | 747 | 168 | -77.57 | 0.68 | 0.21 | -68.31 | -3.84 (-4.19 to −3.49) |
-3.39 (-3.48 to −3.30) | <.001 |
| China | Both | Deaths | 30 to 34 | 1079 | 481 | −55.38 | 1.22 | 0.45 | −63.24 | −3.27 (−3.55 to −3) |
−3.00 (−3.09 to −2.93) | <.001 |
| China | Both | Deaths | 35 to 39 | 1991 | 1110 | −44.25 | 2.17 | 0.94 | −56.82 | −2.8 (−3.03 to −2.57) |
−2.46 (−2.54 to −2.38) | <.001 |
| China | Both | Deaths | 40 to 44 | 3476 | 2095 | −39.74 | 5.17 | 2.3 | −55.42 | −2.82 (−3.09 to −2.55) |
−2.33 (−2.45 to −2.20) | <.001 |
| China | Both | Deaths | 45 to 49 | 6583 | 5237 | −20.44 | 12.72 | 5.25 | −58.72 | −2.86 (−3.06 to −2.65) |
−2.68 (−2.75 to −2.61) | <.001 |
| China | Both | Deaths | 50 to 54 | 14,505 | 13,033 | −10.14 | 30.32 | 11.01 | −63.69 | −3.05 (−3.21 to −2.89) |
−3.02 (−3.09 to −2.95) | <.001 |
| China | Both | Deaths | 55 to 59 | 28,107 | 23,564 | −16.16 | 64.62 | 19.93 | −69.15 | −3.63 (−3.83 to −3.43) |
−3.31 (−3.47 to −3.12) | <.001 |
| China | Both | Deaths | 60 to 64 | 54,680 | 39,906 | −27.02 | 154.24 | 49.01 | −68.23 | −3.6 (−3.79 to −3.42) |
−3.42 (−3.50 to −3.35) | <.001 |
| China | Both | Deaths | 65 to 69 | 83,198 | 76,693 | −7.82 | 303.52 | 100.5 | −66.89 | −3.47 (−3.7 to −3.24) |
−3.30 (−3.40 to −3.21) | <.001 |
| China | Both | Deaths | 70 to 74 | 121,746 | 123,992 | 1.85 | 644.95 | 203.08 | −68.51 | −3.62 (−3.78 to −3.45) |
−3.48 (−3.64 to −3.28) | <.001 |
| China | Both | Deaths | 75 to 79 | 119,294 | 147,142 | 23.34 | 1043.98 | 399.98 | −61.69 | −3 (−3.17 to −2.84) |
−2.85 (−2.98 to −2.71) | <.001 |
| China | Both | Deaths | 80 to 84 | 94,307 | 174,326 | 84.85 | 1688.83 | 776.01 | −54.05 | −2.42 (−2.65 to −2.19) |
−2.38 (−2.46 to −2.31) | <.001 |
| China | Both | Deaths | 85 to 89 | 45,454 | 150,689 | 231.52 | 2277.19 | 1208.2 | −46.94 | −1.78 (−1.99 to −1.57) |
−1.65 (−1.84 to −1.43) | <.001 |
| China | Both | Deaths | 90 to 94 | 11,712 | 77,237 | 559.44 | 3110.29 | 1705.59 | −45.16 | −1.73 (−1.93 to −1.53) |
−1.71 (−1.87 to −1.49) | <.001 |
| China | Both | Deaths | 95 plus | 2010 | 24,457 | 1116.75 | 3069.67 | 1969.78 | -35.83 | −1.33 (−1.53 to −1.12) |
−1.44 (−1.55 to −1.33) | <.001 |
| China | Both | DALYs | 5 to 9 | 20,263 | 10,076 | −50.27 | 19.38 | 9.96 | −48.61 | −2.12 (−2.32 to −1.91) |
−2.02 (−2.10 to −1.97) | <.001 |
| China | Both | DALYs | 10 to 14 | 24,388 | 14,136 | −42.04 | 23.78 | 15.92 | −33.03 | −1.31 (−1.43 to −1.18) |
−1.25 (−1.28 to −1.21) | <.001 |
| China | Both | DALYs | 15 to 19 | 57,543 | 21,040 | −63.44 | 45.31 | 26.12 | −42.36 | −1.7 (−1.79 to −1.62) |
−1.65 (−1.69 to −1.61) | <.001 |
| China | Both | DALYs | 20 to 24 | 87,522 | 24,681 | −71.8 | 66.12 | 34.88 | −47.24 | −2.14 (−2.27 to −2.01) |
−1.85 (−1.89 to −1.81) | <.001 |
| China | Both | DALYs | 25 to 29 | 90,041 | 37,709 | −58.12 | 81.73 | 48.35 | −40.84 | −1.78 (−1.92 to −1.63) |
−1.55 (−1.60 to −1.52) | <.001 |
| China | Both | DALYs | 30 to 34 | 105,660 | 78,085 | −26.1 | 119.39 | 72.69 | −39.11 | −1.67 (−1.78 to −1.55) |
−1.53 (−1.58 to −1.48) | <.001 |
| China | Both | DALYs | 35 to 39 | 162,009 | 133,407 | −17.65 | 176.93 | 112.85 | −36.22 | −1.54 (−1.67 to −1.42) |
−1.33 (−1.37 to −1.29) | <.001 |
| China | Both | DALYs | 40 to 44 | 220,764 | 178,935 | −18.95 | 328.09 | 196.75 | −40.03 | −1.83 (−2.02 to −1.64) |
−1.54 (−1.62 to −1.46) | <.001 |
| China | Both | DALYs | 45 to 49 | 341,399 | 350,417 | 2.64 | 659.62 | 351.31 | −46.74 | −2.05 (−2.19 to −1.91) |
−1.91 (−1.97 to −1.87) | <.001 |
| China | Both | DALYs | 50 to 54 | 636,195 | 729,158 | 14.61 | 1329.89 | 615.86 | −53.69 | −2.31 (−2.42 to −2.19) |
−2.30 (−2.36 to −2.25) | <.001 |
| China | Both | DALYs | 55 to 59 | 1,067,787 | 1,173,304 | 9.88 | 2454.78 | 992.45 | −59.57 | −2.8 (−2.96 to −2.64) |
−2.56 (−2.67 to −2.44) | <.001 |
| China | Both | DALYs | 60 to 64 | 1,744,231 | 1,580,782 | −9.37 | 4919.98 | 1941.32 | −60.54 | −2.94 (−3.09 to −2.78) |
−2.79 (−2.86 to −2.73) | <.001 |
| China | Both | DALYs | 65 to 69 | 2,223,629 | 2,463,367 | 10.78 | 8112.06 | 3227.98 | −60.21 | −2.89 (−3.07 to −2.71) |
−2.76 (−2.86 to −2.68) | <.001 |
| China | Both | DALYs | 70 to 74 | 2,631,709 | 3,166,183 | 20.31 | 13,941.61 | 5185.79 | −62.8 | −3.12 (−3.25 to −2.99) |
−3.02 (−3.16 to −2.86) | <.001 |
| China | Both | DALYs | 75 to 79 | 2,061,548 | 2,885,469 | 39.97 | 18,041.25 | 7843.6 | −56.52 | −2.63 (−2.76 to −2.5) |
−2.51 (−2.62 to −2.39) | <.001 |
| China | Both | DALYs | 80 to 84 | 1,265,160 | 2,557,964 | 102.18 | 22,656.23 | 11,386.72 | −49.74 | −2.14 (−2.34 to −1.95) |
−2.11 (−2.18 to −2.05) | <.001 |
| China | Both | DALYs | 85 to 89 | 481,978 | 1,718,072 | 256.46 | 24,146.48 | 13,775.22 | −42.95 | −1.56 (−1.75 to −1.37) |
−1.46 (−1.63 to −1.27) | <.001 |
| China | Both | DALYs | 90 to 94 | 105,787 | 747,406 | 606.52 | 28,092.15 | 16,504.63 | −41.25 | −1.51 (−1.7 to −1.33) |
−1.52 (−1.67 to −1.32) | <.001 |
| China | Both | DALYs | 95 plus | 17,064 | 217,111 | 1172.35 | 26,059.92 | 17,486.52 | −32.9 | −1.19 (−1.39 to −0.99) |
−1.32 (−1.42 to −1.20) | <.001 |
| United States of America | Both | Incidence | 5 to 9 | 1506 | 1647 | 9.35 | 8.12 | 8.15 | 0.43 | 0.21 (0.02 to 0.39) |
0.03 (0.00 to 0.06) | .044 |
| United States of America | Both | Incidence | 10 to 14 | 1056 | 1418 | 34.35 | 5.99 | 6.74 | 12.54 | 0.47 (0.23 to 0.72) |
0.39 (0.36 to 0.42) | <.001 |
| United States of America | Both | Incidence | 15 to 19 | 1225 | 1515 | 23.64 | 6.75 | 6.86 | 1.73 | −0.15 (−0.36 to 0.07) |
0.03 (0.00 to 0.06) | .045 |
| United States of America | Both | Incidence | 20 to 24 | 1787 | 1950 | 9.17 | 9.11 | 8.98 | −1.44 | −0.34 (−0.49 to −0.19) |
−0.05 (−0.07 to −0.03) | <.001 |
| United States of America | Both | Incidence | 25 to 29 | 2845 | 2865 | 0.72 | 13.08 | 13.04 | −0.31 | −0.27 (−0.36 to −0.18) |
−0.02 (−0.04 to −0.01) | .013 |
| United States of America | Both | Incidence | 30 to 34 | 4259 | 5077 | 19.21 | 19.07 | 21.51 | 12.8 | 0.26 (0.16 to 0.36) |
0.37 (0.36 to 0.39) | <.001 |
| United States of America | Both | Incidence | 35 to 39 | 5517 | 7760 | 40.66 | 27.08 | 34.39 | 26.99 | 0.76 (0.6 to 0.92) |
0.73 (0.71 to 0.76) | <.001 |
| United States of America | Both | Incidence | 40 to 44 | 7537 | 10,537 | 39.81 | 41.71 | 48.09 | 15.28 | 0.52 (0.38 to 0.65) |
0.44 (0.41 to 0.46) | <.001 |
| United States of America | Both | Incidence | 45 to 49 | 8846 | 12,501 | 41.31 | 63.2 | 62.98 | −0.35 | 0.08 (−0.03 to 0.19) |
0.01 (−0.02 to 0.04) | .410 |
| United States of America | Both | Incidence | 50 to 54 | 11,711 | 18,021 | 53.88 | 102.08 | 86.78 | −15 | −0.28 (−0.42 to −0.15) |
−0.47 (−0.52 to −0.42) | <.001 |
| United States of America | Both | Incidence | 55 to 59 | 16,605 | 24,666 | 48.55 | 157.99 | 119.24 | −24.53 | −0.53 (−0.7 to −0.35) |
−0.82 (−0.88 to −0.76) | <.001 |
| United States of America | Both | Incidence | 60 to 64 | 25,985 | 35,336 | 35.99 | 243.86 | 165.8 | −32.01 | −0.76 (−0.95 to −0.56) |
−1.15 (−1.20 to −1.11) | <.001 |
| United States of America | Both | Incidence | 65 to 69 | 36,168 | 43,594 | 20.53 | 358.89 | 226.89 | −36.78 | −0.92 (−1.12 to −0.72) |
−1.37 (−1.40 to −1.33) | <.001 |
| United States of America | Both | Incidence | 70 to 74 | 43,005 | 52,648 | 22.42 | 531.8 | 339.31 | −36.2 | −0.88 (−1.05 to −0.71) |
−1.33 (−1.37 to −1.30) | <.001 |
| United States of America | Both | Incidence | 75 to 79 | 46,462 | 56,970 | 22.62 | 757.66 | 502.16 | −33.72 | −0.79 (−0.94 to −0.64) |
−1.22 (−1.26 to −1.18) | <.001 |
| United States of America | Both | Incidence | 80 to 84 | 40,585 | 47,707 | 17.55 | 1030.74 | 687.24 | −33.33 | −0.88 (−1.01 to −0.75) |
−1.20 (−1.23 to −1.17) | <.001 |
| United States of America | Both | Incidence | 85 to 89 | 27,918 | 34,333 | 22.98 | 1371.53 | 900.43 | −34.35 | −1.06 (−1.2 to −0.93) |
−1.25 (−1.28 to −1.22) | <.001 |
| United States of America | Both | Incidence | 90 to 94 | 12,398 | 19,062 | 53.76 | 1712.21 | 1107.56 | −35.31 | −1.19 (−1.35 to −1.04) |
−1.30 (−1.33 to −1.27) | <.001 |
| United States of America | Both | Incidence | 95 plus | 4600 | 8228 | 78.87 | 2061.87 | 1308.91 | −36.52 | −1.3 (−1.48 to −1.13) |
−1.36 (−1.39 to −1.32) | <.001 |
| United States of America | Both | Prevalence | 5 to 9 | 26,214 | 22,613 | −13.74 | 141.24 | 111.91 | −20.77 | −0.78 (−1.03 to −0.52) |
−0.68 (−0.73 to −0.64) | <.001 |
| United States of America | Both | Prevalence | 10 to 14 | 32,903 | 35,602 | 8.2 | 186.82 | 169.32 | −9.37 | −0.29 (−0.55 to −0.04) |
−0.25 (−0.29 to −0.21) | <.001 |
| United States of America | Both | Prevalence | 15 to 19 | 41,534 | 48,921 | 17.79 | 228.68 | 221.62 | −3.09 | −0.08 (−0.32 to 0.16) |
−0.05 (−0.09 to −0.01) | .026 |
| United States of America | Both | Prevalence | 20 to 24 | 53,703 | 60,114 | 11.94 | 273.75 | 276.65 | 1.06 | 0.03 (−0.19 to 0.26) |
0.08 (0.04 to 0.12) | <.001 |
| United States of America | Both | Prevalence | 25 to 29 | 73,358 | 77,963 | 6.28 | 337.33 | 354.82 | 5.18 | 0.15 (−0.05 to 0.36) |
0.20 (0.16 to 0.24) | <.001 |
| United States of America | Both | Prevalence | 30 to 34 | 95,822 | 112,197 | 17.09 | 429.08 | 475.4 | 10.79 | 0.33 (0.15 to 0.51) |
0.36 (0.33 to 0.40) | <.001 |
| United States of America | Both | Prevalence | 35 to 39 | 115,040 | 154,405 | 34.22 | 564.61 | 684.16 | 21.17 | 0.64 (0.49 to 0.78) |
0.63 (0.59 to 0.66) | <.001 |
| United States of America | Both | Prevalence | 40 to 44 | 137,103 | 218,970 | 59.71 | 758.83 | 999.27 | 31.69 | 0.91 (0.8 to 1.03) |
0.88 (0.85 to 0.91) | <.001 |
| United States of America | Both | Prevalence | 45 to 49 | 146,871 | 284,365 | 93.61 | 1049.23 | 1432.58 | 36.54 | 1 (0.9 to 1.1) |
0.98 (0.95 to 1.00) | <.001 |
| United States of America | Both | Prevalence | 50 to 54 | 168,554 | 415,286 | 146.38 | 1469.3 | 1999.73 | 36.1 | 0.93 (0.83 to 1.03) |
0.96 (0.94 to 0.99) | <.001 |
| United States of America | Both | Prevalence | 55 to 59 | 221,889 | 566,587 | 155.35 | 2111.17 | 2738.88 | 29.73 | 0.69 (0.57 to 0.81) |
0.82 (0.80 to 0.85) | <.001 |
| United States of America | Both | Prevalence | 60 to 64 | 320,567 | 777,274 | 142.47 | 3008.48 | 3647.17 | 21.23 | 0.41 (0.27 to 0.55) |
0.61 (0.58 to 0.63) | <.001 |
| United States of America | Both | Prevalence | 65 to 69 | 426,728 | 897,281 | 110.27 | 4234.33 | 4670.15 | 10.29 | 0.09 (−0.06 to 0.23) |
0.31 (0.30 to 0.33) | <.001 |
| United States of America | Both | Prevalence | 70 to 74 | 466,514 | 902,915 | 93.55 | 5768.95 | 5819.15 | 0.87 | −0.2 (−0.33 to −0.07) |
0.04 (0.02 to 0.06) | <.001 |
| United States of America | Both | Prevalence | 75 to 79 | 459,313 | 814,381 | 77.3 | 7490.09 | 7178.41 | −4.16 | −0.37 (−0.49 to −0.25) |
−0.12 (−0.14 to −0.11) | <.001 |
| United States of America | Both | Prevalence | 80 to 84 | 359,577 | 601,945 | 67.4 | 9132.29 | 8671.34 | −5.05 | −0.4 (−0.52 to −0.29) |
−0.15 (−0.17 to −0.14) | <.001 |
| United States of America | Both | Prevalence | 85 to 89 | 213,048 | 392,194 | 84.09 | 10,466.62 | 10,285.74 | −1.73 | −0.28 (−0.38 to −0.17) |
−0.05 (−0.07 to −0.04) | <.001 |
| United States of America | Both | Prevalence | 90 to 94 | 82,386 | 202,814 | 146.18 | 11,378.22 | 11,783.86 | 3.57 | −0.08 (−0.17 to 0.01) |
0.11 (0.10 to 0.12) | <.001 |
| United States of America | Both | Prevalence | 95 plus | 26,640 | 81,632 | 206.42 | 11,941.4 | 12,986.54 | 8.75 | 0.12 (0.04 to 0.2) |
0.26 (0.24 to 0.27) | <.001 |
| United States of America | Both | Deaths | 5 to 9 | 9 | 3 | −64.66 | 0.05 | 0.02 | −67.54 | −3.73 (−4.31 to −3.16) |
−3.11 (−3.41 to −2.73) | <.001 |
| United States of America | Both | Deaths | 10 to 14 | 7 | 3 | −54.3 | 0.04 | 0.02 | −61.72 | −3.8 (−4.44 to −3.15) |
−2.70 (−2.94 to −2.41) | <.001 |
| United States of America | Both | Deaths | 15 to 19 | 14 | 7 | −49.55 | 0.08 | 0.03 | −58.5 | −2.94 (−3.35 to −2.53) |
−2.55 (−2.90 to −2.19) | <.001 |
| United States of America | Both | Deaths | 20 to 24 | 23 | 13 | −42.86 | 0.12 | 0.06 | −48.41 | −1.85 (−2.31 to −1.39) |
−2.03 (−2.30 to −1.80) | <.001 |
| United States of America | Both | Deaths | 25 to 29 | 35 | 25 | −28.88 | 0.16 | 0.11 | −29.61 | −0.83 (−1.37 to −0.29) |
−0.80 (−1.19 to −0.54) | .008 |
| United States of America | Both | Deaths | 30 to 34 | 64 | 58 | −9.25 | 0.28 | 0.24 | −14.13 | −0.38 (−0.96 to 0.21) |
−0.35 (−0.54 to −0.13) | .003 |
| United States of America | Both | Deaths | 35 to 39 | 102 | 101 | −1.31 | 0.5 | 0.45 | −10.9 | −0.64 (−1.35 to 0.07) |
−0.13 (−0.33 to 0.07) | .195 |
| United States of America | Both | Deaths | 40 to 44 | 160 | 193 | 20.86 | 0.89 | 0.88 | −0.35 | −0.57 (−1.29 to 0.15) |
0.17 (0.00 to 0.34) | .048 |
| United States of America | Both | Deaths | 45 to 49 | 294 | 358 | 22.01 | 2.1 | 1.81 | −13.96 | −0.89 (−1.66 to −0.12) |
−0.31 (−0.51 to −0.08) | .010 |
| United States of America | Both | Deaths | 50 to 54 | 465 | 661 | 42.05 | 4.05 | 3.18 | −21.53 | −1.08 (−1.92 to −0.23) |
−0.51 (−0.70 to −0.33) | <.001 |
| United States of America | Both | Deaths | 55 to 59 | 803 | 1182 | 47.22 | 7.64 | 5.71 | −25.2 | −1.35 (−2.34 to −0.34) |
−0.68 (−0.87 to −0.49) | <.001 |
| United States of America | Both | Deaths | 60 to 64 | 2584 | 3216 | 24.46 | 24.25 | 15.09 | −37.77 | −2.13 (−2.94 to −1.31) |
−1.35 (−1.52 to −1.15) | <.001 |
| United States of America | Both | Deaths | 65 to 69 | 4586 | 4670 | 1.83 | 45.51 | 24.31 | −46.59 | −2.71 (−3.44 to −1.97) |
−1.66 (−1.78 to −1.53) | <.001 |
| United States of America | Both | Deaths | 70 to 74 | 10,277 | 9590 | −6.68 | 127.09 | 61.81 | −51.37 | −2.84 (−3.33 to −2.34) |
−2.05 (−2.17 to −1.90) | <.001 |
| United States of America | Both | Deaths | 75 to 79 | 15,558 | 13,386 | −13.96 | 253.7 | 117.99 | −53.49 | −2.86 (−3.29 to −2.43) |
−2.11 (−2.22 to −1.98) | <.001 |
| United States of America | Both | Deaths | 80 to 84 | 22,474 | 21,505 | −4.31 | 570.79 | 309.8 | −45.72 | −2.27 (−2.57 to −1.96) |
−1.66 (−1.76 to −1.54) | <.001 |
| United States of America | Both | Deaths | 85 to 89 | 21,647 | 25,071 | 15.82 | 1063.47 | 657.52 | −38.17 | −1.87 (−2.16 to −1.58) |
−1.28 (−1.40 to −1.15) | <.001 |
| United States of America | Both | Deaths | 90 to 94 | 13,945 | 23,129 | 65.86 | 1925.96 | 1343.85 | −30.22 | −1.42 (−1.64 to −1.19) |
−1.03 (−1.10 to −0.97) | <.001 |
| United States of America | Both | Deaths | 95 plus | 6533 | 14,845 | 127.23 | 2928.36 | 2361.62 | −19.35 | −0.85 (−1.06 to −0.64) |
−0.56 (−0.63 to −0.51) | <.001 |
| United States of America | Both | DALYs | 5 to 9 | 4211 | 3295 | −21.75 | 22.69 | 16.3 | −28.13 | −1.05 (−1.24 to −0.86) |
−0.94 (−1.00 to −0.89) | <.001 |
| United States of America | Both | DALYs | 10 to 14 | 4866 | 4977 | 2.27 | 27.63 | 23.67 | −14.33 | −0.48 (−0.69 to −0.28) |
−0.42 (−0.46 to −0.38) | <.001 |
| United States of America | Both | DALYs | 15 to 19 | 6406 | 6893 | 7.61 | 35.27 | 31.23 | −11.46 | −0.35 (−0.54 to −0.16) |
−0.32 (−0.38 to −0.26) | <.001 |
| United States of America | Both | DALYs | 20 to 24 | 8558 | 8787 | 2.68 | 43.62 | 40.44 | −7.3 | −0.2 (−0.36 to −0.04) |
−0.18 (−0.24 to −0.12) | <.001 |
| United States of America | Both | DALYs | 25 to 29 | 11,854 | 11,816 | −0.32 | 54.51 | 53.77 | −1.35 | 0.02 (−0.12 to 0.16) |
0.03 (−0.03 to 0.08) | .310 |
| United States of America | Both | DALYs | 30 to 34 | 16,331 | 18,246 | 11.73 | 73.13 | 77.31 | 5.72 | 0.23 (0.14 to 0.32) |
0.20 (0.16 to 0.25) | <.001 |
| United States of America | Both | DALYs | 35 to 39 | 20,415 | 25,597 | 25.38 | 100.2 | 113.42 | 13.2 | 0.4 (0.34 to 0.46) |
0.41 (0.37 to 0.46) | <.001 |
| United States of America | Both | DALYs | 40 to 44 | 25,344 | 37,607 | 48.39 | 140.27 | 171.62 | 22.35 | 0.58 (0.5 to 0.67) |
0.66 (0.60 to 0.70) | <.001 |
| United States of America | Both | DALYs | 45 to 49 | 31,155 | 51,248 | 64.49 | 222.57 | 258.18 | 16 | 0.42 (0.27 to 0.57) |
0.52 (0.45 to 0.58) | <.001 |
| United States of America | Both | DALYs | 50 to 54 | 38,801 | 77,048 | 98.57 | 338.23 | 371.01 | 9.69 | 0.23 (0.03 to 0.43) |
0.38 (0.33 to 0.44) | <.001 |
| United States of America | Both | DALYs | 55 to 59 | 54,924 | 110,598 | 101.36 | 522.58 | 534.63 | 2.31 | −0.08 (−0.34 to 0.19) |
0.16 (0.11 to 0.22) | <.001 |
| United States of America | Both | DALYs | 60 to 64 | 115,332 | 189,870 | 64.63 | 1082.37 | 890.92 | −17.69 | −0.94 (−1.29 to −0.59) |
−0.46 (−0.52 to −0.39) | <.001 |
| United States of America | Both | DALYs | 65 to 69 | 165,581 | 224,243 | 35.43 | 1643.02 | 1167.13 | −28.96 | −1.48 (−1.83 to −1.13) |
−0.93 (−0.99 to −0.86) | <.001 |
| United States of America | Both | DALYs | 70 to 74 | 268,198 | 309,229 | 15.3 | 3316.56 | 1992.93 | −39.91 | −2.01 (−2.32 to −1.69) |
−1.46 (−1.54 to −1.38) | <.001 |
| United States of America | Both | DALYs | 75 to 79 | 315,785 | 330,197 | 4.56 | 5149.56 | 2910.54 | −43.48 | −2.17 (−2.47 to −1.86) |
−1.58 (−1.65 to −1.50) | <.001 |
| United States of America | Both | DALYs | 80 to 84 | 338,083 | 361,430 | 6.91 | 8586.4 | 5206.59 | −39.36 | −1.9 (−2.15 to −1.65) |
−1.38 (−1.46 to −1.29) | <.001 |
| United States of America | Both | DALYs | 85 to 89 | 250,694 | 312,348 | 24.59 | 12,316.06 | 8191.69 | −33.49 | −1.63 (−1.88 to −1.38) |
−1.11 (−1.20 to −1.00) | <.001 |
| United States of America | Both | DALYs | 90 to 94 | 135,147 | 234,908 | 73.82 | 18,664.92 | 13,648.59 | −26.88 | −1.26 (−1.46 to −1.06) |
−0.90 (−0.96 to −0.85) | <.001 |
| United States of America | Both | DALYs | 95 plus | 58,287 | 135,439 | 132.36 | 26,127.29 | 21,546.59 | −17.53 | −0.78 (−0.97 to −0.58) |
−0.50 (−0.56 to −0.45) | <.001 |
Abbreviations: DALY, disability-adjusted life year; CI, confidence interval.
Notes: Age-specific rates per 100,000 population for incidence, prevalence, mortality, and DALYs of ischemic stroke across 19 age groups (<5 to ≥ 95 years) in China and the United States from 1990 to 2023, stratified by sex. For each age group, measure, and sex combination, the table presents baseline values (1990), endpoint values (2023), absolute change, percentage change, and estimated annual percentage change (EAPC) with 95% confidence intervals. This comprehensive age-stratified analysis reveals distinct age-specific temporal patterns in ischemic stroke burden between the 2 countries.