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Proposed two-dimensional model of NixA, the nickel permease of H. pylori. The eight boxes represent the TMs connected by four periplasmic (above the TMs) and three cytoplasmic (below the TMs) loops. The N and C termini reside in the cytoplasm. Amino acids are given in the one-letter code; the ones exchanged in this study are shown in red and numbered. Other conserved amino acids that have not been exchanged in this study are circled.
