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HLA alleles linked to sarcoidosis risk, sources of antigens found in sarcoid lesions and characteristics of immune response of sarcoidosis (adapted from Greaves et al, 2020) [7]
| HLA alleles |
DRB1*12:01, *11:01, *03:01 DQA1*06:02 DQB1*05:03, *06:04 |
| Source of antigens |
Mycobacterium tuberculosis; Cutibacterium acne ; Borrelia burgdorferi; Aspergillus fumigatus Silica; berilium |
| Immune response |
Th1: IFNg and IL-2 Th17: IL-17 and IL-23 Macrophages and epithelioid cells: TNFa |
