FIG. 6.

(Upper panel) Clustering of hemolysin genes (red arrow) of F. nucleatum with those of N. meningitidis, E. coli O157:H7, and P. multocida. Except in the case of E. coli O157:H7, the ORF for hemolysin activator (green arrow) is upstream of the hemolysin gene. The broken lines indicate the presence of insertion elements. The“pinned region” algorithm was used to describe the pattern organization. The yellow, brown, and gray arrows represent ORFs and operons that are not conserved in this hemolysin cluster. (Lower panel) Clustering of a second hemolysin gene (red arrow) of F. nucleatum with those of B. cepacia and Methylobacillus flagellatus. This hemolysin gene in F. nucleatum is truncated.