Table 2.
Paralogous genes, chromosomal locations, protein accession numbers, and important molecular functions for tumor suppressor gene families.
| Genes | Paralogues | Chromosomal location | Protein accession number | Molecular functions |
|---|---|---|---|---|
| CDH1 | ||||
| CDH11 | 16 | P55287 | Calcium ion binding | |
| Adherens junction organization | ||||
| CDH8 | 16 | P55286 | Identical protein binding, calcium ion binding | |
| CDH17 | 8 | Q12864 | Integrin binding, calcium ion binding | |
| PCDH7 | 4 | O60245 | Cyclase activity, antioxidant activity, oxidoreductase activity | |
| CDH20 | 18 | Q9HBT6 | Ligase activity, protein tag activity | |
| JAK2 | ||||
| JAK1 | 1 | P23458 | ATP binding | |
| Growth hormone receptor binding | ||||
| LCK | 1 | P06239 | Identical protein binding, protein kinase binding | |
| PTK2 | 8 | Q05397 | Integrin binding | |
| Protein phosphatase binding | ||||
| FER | 5 | P16591 | Lipid binding | |
| Protein tyrosine kinase binding | ||||
| SRMS | 20 | Q9H3Y6 | ATP binding | |
| Signaling receptor binding | ||||
| PML | ||||
| TRIM66 | 11 | O15016 | Zinc ion binding, nucleoplasm | |
| TRIM5 | 11 | Q9C035 | Protein homodimerization activity, protein kinase binding | |
| TRIM10 | 6 | Q9UDY6 | Ubiquitin protein ligase activity, zinc ion binding | |
| TRIM43 | 2 | Q96BQ3 | – | |
| TRIM43B | 2 | A6NCK2 | Oxidoreductase activity, transferase activity | |
| PTEN | ||||
| TRIM66 | 11 | O15016 | Zinc ion binding, cyclase activity | |
| TRIM5 | 11 | : Q9C035 | Transcription coactivator activity, ubiquitin protein ligase activity | |
| TRIM10 | 6 | Q9UDY6 | Zinc ion binding, lyase activity | |
| TRIM43B | 2 | A6NCK2 | Structural and molecular activity, transporter activity | |
| EXT1 | ||||
| EXTL3 | 8 | O43909 | Magnesium ion binding | |
| Protein hormone receptor activity | ||||
| EXT2 | 11 | Q93063 | Metal ion binding | |
| Protein heterodimerization activity | ||||
| EXTL1 | 1 | Q92935 | Histone binding, protein folding chaperone | |
| EXTL2 | 1 | Q9UBQ6 | Manganese ion binding, lyase activity | |
| NPM1 | ||||
| NPM2 | 8 | Q86SE8 | Histone binding, RNA binding | |
| NPM3 | 10 | O75607 | Chromatin binding, histone binding | |
| VHL | No paralogues | |||
| VHLL | 1 | Q6RSH7 | Dominant-negative VHL that serves as a protector of hypoxia-inducible factor 1-alpha (HIF-1α) | |
| WRN | ||||
| RECQL4 | 8 | O94761 | ATP binding, bubble DNA binding | |
| RECQL5 | 17 | O94762 | ATP binding | |
| Enzyme activator activity | ||||
| BLM | 15 | P54132 | DNA/DNA annealing activity, DNA helicase activity | |
| RECQL | 12 | P46063 | DNA helicase activity, ATP hydrolysis activity | |
| GPC3 | ||||
| GPC5 | 3 | P78333 | DNA binding, RNA binding | |
| GPC2 | 7 | Q8N158 | Ligase activity, protein tag activity | |
| GPC4 | X | O75487 | Catalytic activity, GTPase activity | |
| GPC1 | 2 | P35052 | Copper ion binding | |
| Fibroblast growth factor binding | ||||
| GPC6 | 13 | Q9Y625 | Isomerase activity ligase activity | |
| SOCS1 | ||||
| GPC5 | 13 | P78333 | Cyclase activity, antioxidant activity | |
| GPC2 | 7 | Q8N158 | RNA metabolic process, protein folding | |
| GPC4 | X | O75487 | Hydrolase activity, lyase activity | |
| GPC1 | 2 | P35052 | Copper ion binding | |
| Fibroblast growth factor binding | ||||
| GPC6 | 13 | Q9Y625 | Ligase activity, protein tag activity |