Table 3.
Distribution of isolates showing MIC values above the applicable interpretive threshold (AT) by yeast species and antifungal agent. Only species-drug combinations for which cutoff values (ECVs) were available are included.
| Species | FCZ1 AT/total (%) | ITZ2 AT/total (%) | VOR3 AT/total (%) | PSZ4 AT/total (%) | AND5 AT/total (%) | AMB6 AT/total (%) | Overall AT/total (%) |
|---|---|---|---|---|---|---|---|
| Candida orthopsilosis | 2/2 (100%)* | 2/2 (100%)* | 2/2 (100%)* | 2/2 (100%)* | 0/2 (0%)* | 2/2 (100%)* | 10/12 (83.3%) |
| Candida parapsilosis | 6/6 (100%) | 6/6 (100%)* | 0/6 (0%) | 6/6 (100%)* | 0/6 (0%) | 6/6 (100%)* | 24/36 (66.7%) |
| Clavispora lusitaniae | 4/5 (80%)* | 2/5 (40%)* | – | 5/5 (100%)* | Intrinsic | Intrinsic | 21/25 (84%) |
| Meyerozyma guilliermondii | 11/19 (57.9%)* | 6/19 (31.6%)* | – | 16/19 (84.2%)* | 2/19 (10.5%) | 18/19 (94.7%)* | 53/95 (55.8%) |
| Pichia kudriavzevii | Intrinsic# | 1/1 (100%)* | 0/1 (0%) | 1/1 (100%)* | 1/1 (100%) | – | 4/5 (80%) |
| Wickerhamomyces anomalus | 3/3 (100%)* | 3/3 (100%)* | 3/3 (100%)* | 3/3 (100%)* | – | 3/3 (100%)* | 15/15 (100%) |
| Pichia kluyveri | – | – | – | – | – | 2/4 (50%)* | 2/4 (50%) |
| Trichosporon asahii | – | – | – | – | 6/6 (100%)* | – | 6/6 (100%) |
*
ECV-based classification; #Recognized intrinsic resistance for the combination, with all strains considered as above-threshold.
FCZ1, fluconazole; ITZ2, itraconazole; VOR3, voriconazole; PSZ4, posaconazole; AND5, anidulafungin; AMB6, amphotericin B.