Table 4.
Antifungal susceptibility profiles of the most representative yeast species isolated from captive lizards. MIC data are presented as MIC50, MIC90, and model-estimated central MIC values with corresponding 95% confidence intervals for each antifungal agent tested.
| Species | AMB1 | FCZ2 | ITZ3 | VOR4 | PSZ5 | AND6 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| n | MIC50/MIC90 | Est. MIC* (95% CI) | MIC50/MIC90 | Est. MIC (95% CI) | MIC50/MIC90 | Est. MIC (95% CI) | MIC50/MIC90 | Est. MIC (95% CI) | MIC50/MIC90 | Est. MIC (95% CI) | MIC50/MIC90 | Est. MIC (95% CI) | |
| Artrographis kalrae | 41 | 8/8 | 6.85 (5.26–8.91) | 16/64 | 17.85 (11.78–27.06) | 1/4 | 1.74 (1.18–2.57) | 0.25/0.25 | 0.3 (0.17–0.52) | 1/4 | 1.43 (1.01–2.01) | 2/4 | 2.86 (2.29–3.56) |
| Blastobotrys chiropterorum | 2 | — | — | — | — | — | — | — | — | — | — | — | — |
| Blastobotrys raffinosifermentans | 1 | — | — | — | — | — | — | — | — | — | — | — | — |
| Candida intermedia | 1 | — | — | — | — | — | — | — | — | — | — | — | — |
| Candida orthopsilosis | 2 | — | — | — | — | — | — | — | — | — | — | — | — |
| Candida palmioleophila | 6 | 8/— | 8 (4.02–15.91) | 32/— | 32 (10.82–94.63) | 8/— | 8 (2.92–21.94) | 0.25/— | 0.25 (0.06–1.04) | 2/— | 2 (0.81–4.92) | 4/— | 4 (2.26–7.09) |
| Candida parapsilosis | 6 | 8/— | 8 (4.02–15.91) | 16/— | 28.51 (9.64–84.3) | 1/— | 1.92 (0.69–5.3) | 0.25/— | 0.14 (0.03–0.58) | 1/— | 1.41 (0.57–3.48) | 4/— | 3.17 (1.79–5.63) |
| Clavispora lusitaniae | 5 | 4/— | 5.28 (2.48–11.21) | 8/— | 13.93 (4.25–45.68) | 1/— | 2.91 (0.95–8.9) | 0.03/— | 0.13 (0.03–0.65) | 0.5/— | 0.87 (0.32–2.33) | 1/— | 1.74 (0.93–3.26) |
| Geotrichum candidum | 1 | — | — | — | — | — | — | — | — | — | — | — | — |
| Meyerozyma caribbica | 9 | >64/— | 33.47 (18.28–61.28) | >256/— | 99.92 (38.4–259.99) | >32/— | 52.69 (19.36–143.4) | >32/— | 6.35 (1.82–22.11) | 16/— | 8.64 (4.14–18.02) | 16/— | 14.88 (9.22–24) |
| Meyerozyma guilliermondii | 19 | 8/>64 | 8.55 (5.8–12.62) | 16/>256 | 20.3 (10.99–37.48) | 2/>32 | 4.45 (2.49–7.94) | 0.25/16 | 0.45 (0.2–1) | 1/8 | 1.49 (0.9–2.48) | 4/8 | 3.33 (2.42–4.6) |
| Pichia fermentans | 2 | — | — | — | — | — | — | — | — | — | — | — | — |
| Pichia kluyveri | 4 | — | — | — | — | — | — | — | — | — | — | — | — |
| Pichia kudriavzevii | 1 | — | — | — | — | — | — | — | — | — | — | — | — |
| Torulaspora delbrueckii | 4 | — | — | — | — | — | — | — | — | — | — | — | — |
| Trichosporon asahii | 6 | 4/— | 6.64 (3.32–13.27) | 1/— | 3.37 (1.13–10.04) | 2/— | 3.45 (1.25–9.58) | 0.03/— | 0.1 (0.02–0.44) | 0.5/— | 1.68 (0.68–4.17) | 2/— | 3.28 (1.84–5.83) |
| Wickerhamomyces anomalus | 3 | — | — | — | — | — | — | — | — | — | — | — | — |
AMB1: amphotericin B; FCZ2: fluconazole; ITZ3: itraconazole; VOR4, voriconazole; PSZ5: posaconazole. AND6: anidulafungin. *Est. MIC: model-estimated central value of MIC; 95% CI: 95% confidence interval; —: Not enough data for calculating values.