Table 5.

Model parameter of drug diffusion study

Model	Release parameters	PCG0D	PCG1D	PCG2D	PCG3D	PCG4D
1st order	K 1	0.003 ± 0.000	0.0009 ± 0.001	0.007 ± 0.001	0.004 ± 0.000	0.002 ± 0.000
	R 2	0.829 ± 0.017	0.929 ± 0.011	0.745 ± 0.038	0.611 ± 0.035	0.899 ± 0.042
Higuchi	K H	2.636 ± 0.161	5.418 ± 0.255	4.933 ± 0.208	3.107 ± 0.123	2.232 ± 0.112
	R 2	0.982 ± 0.004	0.887 ± 0.019	0.936 ± 0.019	0.938 ± 0.011	0.974 ± 0.006
Korse Meyer-Peppas	K P	2.665 ± 0.364	12.093 ± 1.017	8.805 ± 1.311	5.586 ± 0.606	1.531 ± 0.307
	n	0.499 ± 0.017	0.327 ± 0.012	0.376 ± 0.025	0.374 ± 0.016	0.584 ± 0.049
	R 2	0.983 ± 0.004	0.985 ± 0.004	0.974 ± 0.003	0.976 ± 0.001	0.984 ± 0.007
Peppas-Shalin	K d	1.292 ± 0.223	7.035 ± 0.754	4.588 ± 0.526	3.401 ± 0.524	-1.971 ± 4.501
	K r	-0.013 ± 0.004	0.203 ± 0.034	-0.093 ± 0.019	-0.079 ± 0.020	1.994 ± 3.460
	m	0.747 ± 0.027	0.556 ± 0.018	0.625 ± 0.009	0.579 ± 0.030	0.650 ± 0.381
	R 2	0.996 ± 0.001	0.993 ± 0.002	0.996 ± 0.002	0.991 ± 0.002	0.997 ± 0.002

K₁ represents the first-order release rate constant, K_H represents the Higuchi rate constant, K_p signifies the release rate constant, n describes the diffusion exponent, K_d is defined as the Fickian diffusion constant, K_r is defined as the case-II relaxation constant, and m is defined as the exponent of diffusion.