Table 5.
Anti-tubercular activity and cytotoxicity of the synthesized compounds and standard drugs
| |||
|---|---|---|---|
| Compd. | R | MIC, μg mL-1 H37RV |
Cytotoxicity, IC50, μg mL-1 RAW 264.7a |
| FP1 |
|
3.12 | 46.19 ± 0.18 |
| FP2 |
|
25 | ND |
| FP3 |
|
1.6 | 96.59 ± 0.16 |
| FP4 |
|
25 | ND |
| FP5 |
|
6.2 | ND |
| FP6 |
|
50 | ND |
| FP7 |
|
25 | ND |
| FP8 |
|
1.6 | 46.28 ± 0.15 |
| FP9 |
|
3.12 | ND |
ND indicates not determined
aRAW 264.7 (murine macrophage) cell lines. The data was analysed using Graph Pad Prism software