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. 2026 Aug 10;17:1876072. doi: 10.3389/fphar.2026.1876072

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Copyright © 2026 Liu, Zhao, Li, Shao, Fan, Kong and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Three vertically oriented medical test reports labeled A, B, and C show data from a GEM Premier 5000 analyzer, each containing patient blood gas analysis values and reference intervals in columns, with right-pointing blue arrow graphics between each report, indicating progression or comparison. — Dynamic changes in arterial blood gas parameters and methemoglobin levels following treatment. (A) Initial arterial blood gas analysis performed on March 10, 2026 before treatment, demonstrating severe methemoglobinemia with a marked oxygen saturation gap. (B) Repeat arterial blood gas analysis on March 11, 2026 after the first administration of methylene blue, showing a marked decrease in methemoglobin level. (C) Follow-up arterial blood gas analysis on March 12, 2026 demonstrating normalization of methemoglobin level and improvement in oxygenation.