Table 4:
SNPs within 50 kb of candidate genes from 2019 MASCC Neurological Complications Working Group Overview. No SNPs were suggestive of genome wide significance (p-value all greater than <1x10–5), therefore this table is only displaying two SNPs within 50 kb from each gene (lowest two p-values).
| CHROMOSOME | GENE POSITION | ALLELE 0 | ALLELE 1 | ALLELE 1 FREQUENCY | BETA | ODDS RATIO | HIGHER 95% CI | LOWER 95% CI | P-VALUE | GENE WITHIN 50 KB OF SNP |
|---|---|---|---|---|---|---|---|---|---|---|
| 18 | 63919403 | A | C | 23% | −1.05E-05 | 1.00 | 1.29 | 0.77 | 2.78E-05 | SERPINB2 |
| 16 | 82622189 | C | T | 18% | −1.35E-05 | 1.00 | 1.31 | 0.76 | 3.41E-05 | CDH13 |
| 4 | 65396784 | A | G | 25% | 2.14E-05 | 1.00 | 1.28 | 0.78 | 5.93E-05 | EPHA5 |
| 16 | 83513791 | C | T | 5% | 4.39E-05 | 1.00 | 1.63 | 0.61 | 6.08E-05 | CDH13 |
| 8 | 1919487 | T | C | 6% | −8.24E-05 | 1.00 | 1.59 | 0.63 | 1.21E-04 | ARHGEF10 |
| 18 | 53317052 | T | C | 10% | −7.17E-05 | 1.00 | 1.42 | 0.70 | 1.39E-04 | DCC |
| 18 | 53322836 | A | C | 10% | −7.17E-05 | 1.00 | 1.42 | 0.70 | 1.39E-04 | DCC |
| 13 | 95295322 | C | T | 9% | −1.05E-04 | 1.00 | 1.49 | 0.67 | 1.79E-04 | ABCC4 |
| 2 | 203897604 | G | T | 21% | 8.54E-05 | 1.00 | 1.30 | 0.77 | 2.20E-04 | CTLA4 |
| 19 | 45401800 | CA | C | 24% | −8.55E-05 | 1.00 | 1.28 | 0.78 | 2.35E-04 | ERCC1 |
| 19 | 45401800 | CA | C | 24% | −8.55E-05 | 1.00 | 1.28 | 0.78 | 2.35E-04 | ERCC2 |
| 8 | 1816739 | C | A | 47% | −8.45E-05 | 1.00 | 1.23 | 0.81 | 2.77E-04 | ARHGEF10 |
| 4 | 182810730 | A | T | 16% | 1.27E-04 | 1.00 | 1.33 | 0.75 | 2.99E-04 | TENM3 |
| 13 | 95075607 | G | A | 14% | −1.59E-04 | 1.00 | 1.37 | 0.73 | 3.45E-04 | ABCC4 |
| 4 | 182348375 | C | T | 5% | 2.57E-04 | 1.00 | 1.61 | 0.62 | 3.69E-04 | TENM3 |
| 19 | 43545729 | G | T | 5% | 2.67E-04 | 1.00 | 1.64 | 0.61 | 3.69E-04 | XRCC1 |
| 1 | 151835038 | G | A | 17% | 1.63E-04 | 1.00 | 1.33 | 0.75 | 3.87E-04 | THEM5 |
| 1 | 151831288 | C | G | 14% | −1.96E-04 | 1.00 | 1.38 | 0.72 | 4.12E-04 | THEM5 |
| 6 | 3157554 | C | T | 5% | 3.10E-04 | 1.00 | 1.62 | 0.62 | 4.36E-04 | TUBB2A |
| 7 | 87467135 | GTGCTGT | G | 3% | 4.09E-04 | 1.00 | 1.80 | 0.56 | 4.73E-04 | ABCB1 |
| 9 | 104789771 | C | CCACT | 12% | 2.48E-04 | 1.00 | 1.40 | 0.72 | 5.07E-04 | ABCA1 |
| 12 | 32451710 | C | T | 16% | −2.17E-04 | 1.00 | 1.34 | 0.75 | 5.09E-04 | FGD4 |
| 2 | 221583972 | T | G | 43% | 2.03E-04 | 1.00 | 1.24 | 0.81 | 6.39E-04 | EPHA4 |
| 7 | 87568035 | G | A | 38% | −2.00E-04 | 1.00 | 1.23 | 0.81 | 6.53E-04 | ABCB1 |
| 4 | 65330904 | C | A | 36% | −2.99E-04 | 1.00 | 1.26 | 0.80 | 8.92E-04 | EPHA5 |
| 16 | 70697967 | C | T | 3% | −8.58E-04 | 1.00 | 1.81 | 0.55 | 9.80E-04 | VAC14 |
| 19 | 1213879 | C | T | 6% | 7.17E-04 | 1.00 | 1.60 | 0.63 | 1.04E-03 | MIDN |
| 12 | 32538144 | T | C | 30% | 3.95E-04 | 1.00 | 1.26 | 0.79 | 1.16E-03 | FGD4 |
| 3 | 96894070 | G | C | 6% | 7.72E-04 | 1.00 | 1.57 | 0.64 | 1.16E-03 | EPHA6 |
| 3 | 97100763 | A | G | 19% | 4.94E-04 | 1.00 | 1.32 | 0.76 | 1.23E-03 | EPHA6 |
| 2 | 221505338 | A | T | 48% | −4.36E-04 | 1.00 | 1.24 | 0.80 | 1.36E-03 | EPHA4 |
| 6 | 170506340 | C | T | 4% | 1.09E-03 | 1.00 | 1.71 | 0.59 | 1.39E-03 | PSMB1 |
| 15 | 34261956 | G | A | 34% | 4.82E-04 | 1.00 | 1.26 | 0.79 | 1.40E-03 | SLC12A6 |
| 19 | 10297763 | A | C | 7% | 8.95E-04 | 1.00 | 1.52 | 0.66 | 1.45E-03 | ICAM1 |
| 20 | 38086209 | G | C | 6% | −1.11E-03 | 1.00 | 1.62 | 0.62 | 1.57E-03 | RPRD1B |
| 9 | 104916516 | C | T | 27% | −5.97E-04 | 1.00 | 1.28 | 0.78 | 1.64E-03 | ABCA1 |
| 16 | 70694074 | G | C | 43% | −5.34E-04 | 1.00 | 1.24 | 0.81 | 1.68E-03 | VAC14 |
| 10 | 95100709 | T | G | 48% | 6.32E-04 | 1.00 | 1.24 | 0.81 | 2.02E-03 | CYP2C8 |
| 19 | 45354988 | G | A | 6% | −1.60E-03 | 1.00 | 1.67 | 0.60 | 2.12E-03 | ERCC2 |
| 19 | 45364748 | T | A | 44% | 6.76E-04 | 1.00 | 1.24 | 0.81 | 2.13E-03 | ERCC1 |
| 20 | 38059968 | C | G | 19% | −9.29E-04 | 1.00 | 1.32 | 0.76 | 2.29E-03 | RPRD1B |
| 2 | 203894729 | A | G | 16% | −1.40E-03 | 1.00 | 1.34 | 0.74 | 3.22E-03 | CTLA4 |
| 19 | 10323992 | T | C | 15% | 1.51E-03 | 1.00 | 1.35 | 0.74 | 3.48E-03 | ICAM1 |
| 6 | 170583923 | T | C | 4% | −2.75E-03 | 1.00 | 1.68 | 0.59 | 3.62E-03 | PSMB1 |
| 10 | 95004848 | A | G | 3% | 3.22E-03 | 1.00 | 1.84 | 0.55 | 3.62E-03 | CYP2C8 |
| 15 | 34285822 | T | C | 27% | 1.29E-03 | 1.00 | 1.28 | 0.79 | 3.62E-03 | SLC12A6 |
| 6 | 3138184 | A | AT | 35% | 1.30E-03 | 1.00 | 1.27 | 0.79 | 3.76E-03 | TUBB2A |
| 18 | 63908773 | A | G | 23% | −1.51E-03 | 1.00 | 1.28 | 0.78 | 4.09E-03 | SERPINB2 |
| 21 | 43028665 | G | A | 39% | −1.40E-03 | 1.00 | 1.24 | 0.80 | 4.36E-03 | PKNOX1 |
| 1 | 109677464 | C | G | 45% | 1.58E-03 | 1.00 | 1.23 | 0.82 | 5.30E-03 | GTSM1 |
| 19 | 43533218 | C | G | 17% | −2.37E-03 | 1.00 | 1.33 | 0.75 | 5.69E-03 | XRCC1 |
| 21 | 42978791 | GT | G | 5% | 4.47E-03 | 1.00 | 1.68 | 0.60 | 5.94E-03 | PKNOX1 |
| 11 | 67623375 | A | G | 13% | −2.74E-03 | 1.00 | 1.36 | 0.73 | 5.99E-03 | GSTP1 |
| 11 | 67623890 | A | C | 13% | −2.74E-03 | 1.00 | 1.36 | 0.73 | 5.99E-03 | GSTP1 |
| 19 | 1254123 | G | A | 41% | −2.03E-03 | 1.00 | 1.24 | 0.80 | 6.42E-03 | MIDN |
| 6 | 35412221 | G | A | 13% | −3.82E-03 | 1.00 | 1.38 | 0.72 | 8.08E-03 | PPARD |
| 1 | 109665467 | A | T | 37% | −2.52E-03 | 1.00 | 1.23 | 0.81 | 8.34E-03 | GTSM1 |
| 1 | 52591811 | G | A | 27% | −3.38E-03 | 1.00 | 1.27 | 0.78 | 9.62E-03 | GPX7 |
| 6 | 35311019 | C | A | 20% | 4.24E-03 | 1.00 | 1.31 | 0.77 | 1.09E-02 | PPARD |
| 5 | 664090 | C | CG | 12% | 5.58E-03 | 1.01 | 1.41 | 0.72 | 1.15E-02 | CEP72 |
| 1 | 52630054 | T | C | 10% | 6.19E-03 | 1.01 | 1.45 | 0.70 | 1.17E-02 | GPX7 |
| 7 | 99609320 | A | C | 6% | 8.49E-03 | 1.01 | 1.62 | 0.63 | 1.23E-02 | CYP3A5 |
| 5 | 87437561 | A | G | 3% | 1.18E-02 | 1.01 | 1.89 | 0.54 | 1.31E-02 | CCNH |
| 5 | 669327 | G | A | 3% | −1.23E-02 | 0.99 | 1.87 | 0.52 | 1.32E-02 | CEP72 |
| 7 | 99642556 | A | G | 10% | 9.04E-03 | 1.01 | 1.48 | 0.69 | 1.64E-02 | CYP3A5 |
| 5 | 87375153 | T | C | 47% | −1.16E-02 | 0.99 | 1.23 | 0.79 | 3.70E-02 | CCNH |