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. 2026 Aug 11;14:1857511. doi: 10.3389/fped.2026.1857511

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© 2026 Xie, Sui, Zhang, Zhang, Li, Sun and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Timeline and line graph illustrating a newborn's clinical course: hypotonia at birth, genetic testing on day 3, diagnosis on day 5, four nusinersen doses through day 68, longitudinal follow-up, and CHOP-INTEND motor scores increasing from six to thirty. — Clinical timeline of diagnosis and treatment. Timeline illustrating key clinical events from birth to day 68 of life, including genetic diagnosis, nusinersen administration, respiratory support changes, and serial CHOP-INTEND assessments.