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. 2005 Jul 29;1(3):241–247. doi: 10.1007/s11302-005-6310-1

Figure 3.

Figure 3

Effects of MRS2179 on ADP-induced calcium mobilization in astrocytoma cells. (A) MRS2179 was used to antagonize the effects of the agonist ADP in the calcium mobilization assay. The MRS2179 concentration was fixed at either 0, 5×10−6, 10−6, 10−5, or 5×10−4 (M) over an ADP range of 10−10 to 10−5 (M). Increasing amounts of antagonist cause a right shift in the curves. Each experimental data point was done in duplicate and averaged. (B) A Schild analysis was performed to calculate a KB of 164 nM.