Table IV.
Interaction of genotypes with cigarette smoking
| MALE | FEMALE | ALL | ||||
|---|---|---|---|---|---|---|
| Genotype | Smoke | Case/Con n/n | AOR (95% CI)* | Case/Con n/n | AOR (95% CI)* | AOR (95% CI)* |
| CYP1A2*1D | ||||||
| T/T | Never | 36/33 | 1.0 (referent) | 28/41 | 1.0 (referent) | 1.0 (referent) |
| T/delT & delT/delT | Never | 27/31 | 0.8 (0.4 – 1.6) | 22/43 | 0.8 (0.4 – 1.7) | 0.8 (0.5 – 1.3) |
| T/T | Ever | 66/58 | 0.9 (0.5 – 1.7) | 36/26 | 1.9 (0.9 – 4.2) | 1.2 (0.8 – 2.0) |
| T/delT & delT/delT | Ever | 56/54 | 0.9 (0.5 – 1.7) | 36/30 | 1.9 (0.9 – 4.1) | 1.2 (0.8 – 2.0) |
| CYP1A2*1F | ||||||
| CC | Never | 26/27 | 1.0 (referent) | 25/48 | 1.0 (referent) | 1.0 (referent) |
| AC/AA | Never | 36/38 | 0.8 (0.4 – 1.8) | 26/38 | 1.3 (0.6 – 2.8) | 1.1 (0.7 – 1.9) |
| CC | Ever | 50/51 | 0.9 (0.4 – 1.8) | 28/30 | 2.1 (1.0 – 4.5) | 1.4 (0.8 – 2.3) |
| AC/AA | Ever | 71/61 | 0.9 (0.5 – 1.8) | 45/27 | 3.0 (1.4 – 6.6) | 1.6 (1.0 – 2.7) |
| NAT1 | ||||||
| Reference | Never | 37/46 | 1.0 (referent) | 28/58 | 1.0 (referent) | 1.0 (referent) |
| Rapid | Never | 25/15 | 2.1 (0.9 – 4.9) | 24/24 | 2.3 (1.0 – 4.9) | 2.2 (1.3 – 3.8) |
| Reference | Ever | 75/70 | 1.2 (0.6 – 2.0) | 45/36 | 2.5 (1.2 – 5.2) | 1.7 (1.1 – 2.6) |
| Rapid | Ever | 42/38 | 1.2 (0.6 – 2.4) | 29/20 | 3.4 (1.5 – 7.6) | 1.9 (1.1 – 3.1) |
| NAT2 | ||||||
| Rapid & Intermediate | Never | 23/23 | 1.0 (referent) | 24/35 | 1.0 (referent) | 1.0 (referent) |
| Slow | Never | 32/35 | 1.0 (0.4 – 2.1) | 28/47 | 0.9 (0.4 – 2.0) | 0.9 (0.5 – 1.6) |
| Rapid & Intermediate | Ever | 42/47 | 0.8 (0.4 – 1.7) | 25/22 | 1.6 (0.7 – 3.7) | 1.1 (0.6 – 1.9) |
| Slow | Ever | 63/61 | 1.0 (0.5 – 2.0) | 44/33 | 2.0 (0.9 – 4.3) | 1.3 (0.8 – 2.2) |
*
Obtained from a logistical regression model with adjustment for age, diabetes, pancreatitis and ethanol intake (all as categorical variables).