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. 2026 Aug 12;17:1907116. doi: 10.3389/fimmu.2026.1907116

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Copyright © 2026 Li, Mu, Guo, Zheng, Yang, Wang, Shi, Xu, Tian, Ma and Zhao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bar and line chart comparing clinical outcome measures by ENI-Score benefit groups. Panel A shows high-benefit groups with higher rates in MPR, pCR, ORR, and ypN0. Panel B shows higher recurrence-free survival over time for high-benefit groups, with significant differences across groups. — Clinical stratification by the ENI-Score: (A) rates of MPR, pCR, ORR, and ypN0 across the Low-, Intermediate-, and High-benefit groups; (B) Kaplan–Meier recurrence-free survival curves for the three ENI-Score groups. The between-group difference was significant by the log-rank test (P<0.001).