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. Author manuscript; available in PMC: 2006 Sep 1.
Published in final edited form as: FEBS J. 2005 Sep;272(18):4725–4740. doi: 10.1111/j.1742-4658.2005.04888.x

Table 6.

Effect of plant polyphenols on MRP-mediated transport in membrane vesicles prepared from human erythrocytes

Polyphenol MRP1-mediated DNP-SG transportaIC50[μM]b MRP4-mediated cGMP transportaIC50[μM]b
Quercetin 45.12 ± 11.93 1.16 ± 0.17
Silymarin 0.26 ± 0.06 0.91 ± 0.11
Naringenin 23.70 ± 5.99 3.37 ± 0.28
Hesperetin 70.18 ± 40.24 2.46 ± 0.14
Resveratrol 169.9 ± 53.0
17.12 ± 6.15
(58.3 ± 4.6 % UI)		 1.66 ± 0.14
Daidzein No effect 9.67 ± 1.55
a

The transport of [3H]DNP-SG and [3H]cGMP in inside-out membrane vesicles of human erythrocytes was determined in the presence and absence of indicated polyphenols as described in the experimental procedures.

b

IC50 values are mean ± S.D in the presence and absence of flavonoids. The IC50 values were calculated from dose response curves obtained from three independent experiments.