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. 2005 Dec;171(4):1463–1475. doi: 10.1534/genetics.105.046458

Figure 2.

Figure 2.

Design of replacement CENs containing randomized CDEII. The middle line shows the consensus sequence of the 16 endogenous S. cerevisiae centromeres where the height of each letter is proportional to its frequency of occurrence at that position (Schneider and Stephens 1990). The sequence logos were generated by WebLogo (Crooks et al. 2004). Below the consensus sequence is shown the DNA sequence of the replacement centromeres generated by ligation of the randomized CDEII segments into the pRB507 vector (see materials and methods).