Table 2.

Frequency of antibody response to recombinant H–Y proteins and H–X homologs in male patients who underwent transplantation and in healthy individuals

	DBY	UTY	ZFY	RPS4Y	EIF1AY	≥1 H–Y	≥2 H–Y	≥1 H–X
F→M HSCT, n = 75 (%)	35 (46.6)	18 (24)	12 (16)	4 (5.3)	6 (8)	39 (52)	23 (30.6)	13 (17.3)
M→M HSCT, n = 46, (%)	0	0	4 (8.7)	0	0	4 (8.7)	0	6 (13)
Male donors, n = 64 (%)	1 (1.6)	0	0	1 (1.6)	3 (4.7)	5 (7.8)	0	5 (7.8)
Female donors, n = 70 (%)	11 (15.7)	4 (5.7)	3 (4.3)	15 (21.4)	9 (12.9)	29 (41.4)	8 (11.4)	12 (17.1)

Statistical comparisons: DBY, UTY, ≥1 H–Y, ≥2 H–Y antibody frequency between male recipients with female donors (F→M HSCT) and either male recipients with male donors (M → M HSCT) or healthy males; P < .001, 2-sided Fisher exact test. DBY, UTY, ZFY, RPS4Y, and ≥2 H–Y antibody frequency between F → M HSCT and healthy females; P < .008, 2-sided Fisher exact test. DBY, RPS4Y, ≥1 H–Y, and ≥2 H–Y antibody frequency between female donors and male donors; P < .007, 2-sided Fisher exact test. Comparison of ≥1 H–Y with ≥1 H–X in F→M HSCT and healthy females; P < .0001, 2-sided McNemar test.