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Encephalitogenic T cells are less effective at inducing EAE when transferred into MyD88- or TLR9-deficient hosts. Adoptive transfer of MOG-reactive T cells (25 × 106 cells) into MyD88–/– or TLR9–/– but not TLR2–/– hosts results in milder disease. Data shown are from 1 representative experiment of at least 2 individual experiments with at least 5 mice per group (means). Asterisks indicate statistical significance. P < 0.05.
