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. Author manuscript; available in PMC: 2006 Jan 25.
Published in final edited form as: Oncogene. 2004 Apr 22;23(19):3404–3413. doi: 10.1038/sj.onc.1207397

Figure 3.

Figure 3

Effect of MEK inhibition on KLF5 expression in H-Ras-transformed cells. Panel a shows the MAPK activity in NIH3T3, Ras 2 and Ras 7 cells as determined by the level of pERK1/2 (top row). The total amounts of ERK1/2 were determined by Western blot analysis using specific antibodies (bottom row). Panels b and c show the results of Northern blot analysis of RNA extracted from Ras 2 and Ras 7 cells, respectively, after treatment with two MEK inhibitors, PD98059 (PD) and U0126 (U). − indicates untreated cells. Panels d and e show the results of Western blot analysis of proteins extracted from Ras 2 and Ras 7 cells, respectively, after treatment with two MEK inhibitors, PD98059 (PD) and U0126 (U). − indicates untreated cells