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Inhibitors of P. furiosus FBPase activitya
| Effector | IC50 (mM) |
|---|---|
| Li+ | 1 |
| Ca2+ | 5 |
| AMP | 30 |
| ADP | 3 |
| ATP | 4 |
| Glucose-6-phosphate | 4 |
| Fructose-6-phosphate | 25 |
| Pyruvate | 60 |
Enzyme assays were performed at 85°C as described in the text (10 mM fructose-1,6-bisphosphate). IC50, the concentration of the effector when activity of the P. furiosus FBPase was reduced by 50%. The addition of up to 100 mM Na+, K+, glucose, or PEP to the assay mixture had no effect on FBPase activity.
