Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2006 Jan 25.

Published in final edited form as: J Biol Chem. 2003 Dec 18;279(11):10422–10432. doi: 10.1074/jbc.M312410200

Fig. 6 — A and B, serial responses to increasing flash stimuli obtained from Lrat+/+ and Lrat−/− mice in dark-adapted (upper A panel) and light-adapted (upper B panel) conditions. Plotted ERG responses (a-wave and b-wave amplitudes) to increasing light stimuli in Lrat−/− show significantly lower responses compared with Lrat+/+ in both conditions (lower A panel, p < 0.0001; lower B panel, p < 0.01, one-way ANOVA). Light-adapted responses are examined after bleaching at 1.4 log cd·m⁻² for 15 min. C, leading edges (initial 5–20 ms depending on response) of dark-adapted ERG photoresponses (symbols) evoked by 2.8-(filled circles) and 1.6-(open circles) log cd·s·m⁻² flashes, are fit with a model of phototransduction (smooth lines). The amplitude and sensitivity of the Lrat−/− mouse photoresponses are reduced from maximal responses. D, maximum a-wave amplitude and sensitivity parameters of dark-adapted photoresponses in Lrat−/− mice compared with the results in Lrat+/+ mice. Lrat−/− mice show significant differences in both parameters (*, p < 0.0001; **, p < 0.001, one-way ANOVA) compared with Lrat+/+ mice. Error bars represent 1 S.E. in A and B.

Fig. 6 — A and B, serial responses to increasing flash stimuli obtained from Lrat+/+ and Lrat−/− mice in dark-adapted (upper A panel) and light-adapted (upper B panel) conditions. Plotted ERG responses (a-wave and b-wave amplitudes) to increasing light stimuli in Lrat−/− show significantly lower responses compared with Lrat+/+ in both conditions (lower A panel, p < 0.0001; lower B panel, p < 0.01, one-way ANOVA). Light-adapted responses are examined after bleaching at 1.4 log cd·m⁻² for 15 min. C, leading edges (initial 5–20 ms depending on response) of dark-adapted ERG photoresponses (symbols) evoked by 2.8-(filled circles) and 1.6-(open circles) log cd·s·m⁻² flashes, are fit with a model of phototransduction (smooth lines). The amplitude and sensitivity of the Lrat−/− mouse photoresponses are reduced from maximal responses. D, maximum a-wave amplitude and sensitivity parameters of dark-adapted photoresponses in Lrat−/− mice compared with the results in Lrat+/+ mice. Lrat−/− mice show significant differences in both parameters (*, p < 0.0001; **, p < 0.001, one-way ANOVA) compared with Lrat+/+ mice. Error bars represent 1 S.E. in A and B.