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. Author manuscript; available in PMC: 2006 Jan 25.
Published in final edited form as: Biochem Pharmacol. 2003 Nov 1;66(9):1755–1768. doi: 10.1016/s0006-2952(03)00542-2

TABLE 2.

Activity of hydroxamate containing analogues in stimulating γ-globin transcription after 96 hours exposure in K562/HS2γ cells.

Compound Structure EC50 (uM) Maximal Fold Induction
acetohydroxamic acid graphic file with name nihms3499f16.jpg 250 2.6
propionohydroxamic acid graphic file with name nihms3499f17.jpg 30 4.7
R-02210 graphic file with name nihms3499f18.jpg 50 5.5
R-02761 graphic file with name nihms3499f19.jpg 4 3
R-44534 graphic file with name nihms3499f20.jpg 50 4.1
15260 graphic file with name nihms3499f21.jpg - no effect
NS41080 graphic file with name nihms3499f22.jpg 5 4
NS43789 graphic file with name nihms3499f23.jpg 40 4