TABLE 3.

Maximum fold inductions of 9 stress response reporter constructs by γ-globin transcription inducing and control compounds.

Compound	[Compound] μ M	Markers Induced >2 Fold (p ≤ 0.05)	Fold Induction	% Max	p
Control Compounds
3-Methyl Cholanthrene	20	GST Ya (8 hr)	2.7	20	0.007
	20	GST Ya (24 hr)	5.0	100	0.004
	7	HIF1RE	3.7	100	0.006
	20	XRE	5.5	48	0.001
Calcium ionophore (A23187)	2	HSP70	3.3	8	0.020
	20	NF-AT	11.4	100	0.001
Methane methyl sulfonate (MMS)	1000	CJUN	10.1	100	0.000
	1000	GADD153	15.2	58	0.000
	333	GST Ya (8 hr)	4.7	40	0.012
	333	HSP70	5.9	24	0.036
	333	XRE	2.1	12	0.004
12-phorbol 13-myristate (PMA)	0.7	CJUN	8.1	78	0.000
	0.2	GADD153	25.5	100	0.001
	0.7	GST Ya (8 hr)	10.2	100	0.001
	0.2	HMO	19.8	100	0.001
	0.2	HSP70	21.7	100	0.004
	0.7	NF-κ BRE	1030.0	100	0.004
	2	NF-AT	8.6	60	0.029
	0.7	XRE	10.2	98	0.019
Test Compounds
OSI-97345	17	GST Ya (8 hr)	2.5	16	0.005
	17	GST Ya (24 hr)	2.8	38	0.010
	6	HSP70	2.4	7	0.028
	17	XRE	5.0	44	0.000
OSI-102695	4.2	GST Ya (24 hr)	2.0	18	0.043
	1.4	HSP70	2.1	4	0.043
	13	XRE	2.5	16	0.003
OSI-101820	14	XRE	2.9	20	0.001
OSI-168992	1.9	HIF1RE	2.2	48	0.000
	0.6	XRE	2.8	20	0.003
OSI-168961	8	HIF1RE	2.4	79	0.035
	3	XRE	2.3	15	0.006
OSI-169050	14	GADD153	2.3	6	0.004
	42	GST Ya (8 hr)	2.3	13	0.009
	125	GST Ya (24 hr)	2.5	27	0.003
	42	HIF1RE	3.3	95	0.000
	42	XRE	3.9	32	0.002
OSI-169170	42	GADD153	2.1	5	0.001
	14	GST Ya (8 hr)	2.1	12	0.019
OSI-2040	10	CJUN	2.0	11	0.006
	10	GADD153	2.1	4	0.000
	0.4	HSP70	6.8	28	0.022
	10	NF-κ BRE	4.1	0	0.022
	0.1	XRE	4.2	34	0.006
Proprionohydroxamic acid (PHA)	< 50	None	-	-	-