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. Author manuscript; available in PMC: 2006 Jan 26.
Published in final edited form as: Angew Chem Int Ed Engl. 2005 Oct 14;44(40):6525–6529. doi: 10.1002/anie.200501603

Figure 4.

Figure 4

Metabolic stability of HBS α helices. HPLC assay shows rapid proteolysis of a) the unconstrained peptide 1 in the presence of trypsin, whereas b) the HBS α helix 2a degrades at a much slower rate. Tryptophan (500 μm) was used as an internal control for the HPLC studies. c) Comparison of the initial velocities for the proteolysis of Bak BH3 1 (k = 18.0 μm min−1, -----⋄-----), HBS helix 2a (k = 0.60 μm min−1, – – –□– – –), and HBS helix 2b (k = 0.30 μm min−1, —▪—).