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. Author manuscript; available in PMC: 2006 Jan 26.
Published in final edited form as: J Mol Evol. 2004 Aug;59(2):204–217. doi: 10.1007/s00239-004-2614-y

Fig. 6.

Fig. 6.

Phylogenetic analysis of GCAPs and GCs. A A phylogenetic tree calculated from the amino acid sequences of GCAPs. Numbers at the nodes indicate the clustering percentage obtained from 1000 bootstrap resamplings. Bar indicates 10% replacement of an amino acid per site (k = 0.1; see Materials and Methods). The diamonds located at the nodes indicate the estimated gene duplication events. Sequence data used in the present analyses were taken from the GenBank, EMBL, SWISS-PROT, and NCBI databases, except for mouse GCAP2. The accession numbers for the amino acid sequences are as follows: bGCAP1 (Bos taurus), AAB31698; hGCAP1 (Homo sapiens), P_00040; mGCAP1 (Mus musculus), NP_03221; accession rGCAP1, composite sequence of two overlapping ESTs (BF543297 and AI579371), 27681847; cGCAP1 (Gallus gallus), P79880; fuGCAP1 (Rana pipiens) O73761; zGCAP1, AAK95947; fuGCAP1 (Takifugu rubripes), CAD12779; siluGCAP1 (Silurana tropicalis), translated from EST AL874865 (unpublished); oryGCAP1 (Oryzias latipes), BAB83093; bGCAP2, translated from L43001; hGCAP2, 8928106; mGCAP2 (taken from Howes et al. 1998); sbGCAP2 (striped bass; Morone saxatilis), K. Zhang and W. Baehr, unpublished; cGCAP2 (Gallus gallus), P79881; fuGCAP2 (Rang pipiens), O73762; siluGCAP2 (Silurana tropicalis), translated from EST AL797721; oryGCAP2 (Oryzias latipes), BAB83094; fuGCAP2, CAD12780; zGCAP2 (Danio rerio), AAK95948; hGCAP3, (Homo sapiens), AAD19944; zGCAP3 (Danio rerio), AAK95949; zGCAP4, 5, 7, (to be submitted to GenBank); fuGCIP (Rana pipiens), O73763. B A phylogenetic tree calculated from the amino acid sequences of photoreceptor GCs. Conserved amino acid sequences including transmembrane domain and intracellular domains are used for calculation. Bar indicates 10% replacement of an amino acid per site (k = 0.1; see Materials and Methods). The accession numbers of the amino acid sequences are as follows: bovine GC1, AAB86385; human GC1, Q02846; rat GC1, P51840; bovine GC2, O02740: human GC2, P51841; rat GC2, P51842; bovine GColf, AAC31208. For teleost olGC accession numbers, see Materials and Methods.