Table 3.
HLA-DR,DQ genotype frequencies and odds ratios, by age at onset of type 1 diabetes mellitus (T1DM)
| Onset age 0–4 (n = 279)
|
Onset age 5–9 (n = 443)
|
Onset age 10–14 (n = 390)
|
Onset age 15–29 (n = 210)
|
Controls (n = 3339) | |||||
|---|---|---|---|---|---|---|---|---|---|
| HLA-DR,DQB1 | n (%) | OR (95% CI) | n (%) | OR (95% CI) | n (%) | OR (95% CI) | n (%) | OR (95% CI) | n (%) |
| 3/4,*0302 | 131 (47.0) | 37.01 (26.73–51.22) | 112 (25.3) | 14.15 (10.37–19.29) | 121 (31.0) | 19.38 (14.20–26.46) | 36 (17.1) | 8.65 (5.66–13.21) | 78 (2.34) |
| 4/4,*0302 | 30 (10.75) | 3.90 (2.54–5.99) | 52 (11.74) | 4.31 (3.03–6.12) | 34 (8.72) | 3.09 (2.06–4.63) | 30 (14.29) | 5.40 (3.50–8.34) | 100 (2.99) |
| 1/4,*0302 | 12 (4.30) | 1.96 (1.05–3.64) | 41 (9.26) | 4.44 (2.99–6.59) | 25 (6.41) | 2.98 (1.87–4.74) | 18 (8.57) | 4.08 (2.39–6.96) | 75 (2.25) |
| 8/4,*0302 | 4 (1.43) | 0.96 (0.34–2.67) | 13 (2.93) | 1.99 (1.07–3.69) | 11 (2.82) | 1.91 (0.99–3.70) | 8 (3.81) | 2.61 (1.22–5.57) | 50 (1.50) |
| 9/4,*0302 | 1 (0.36) | 1.09 (0.14–8.46) | 8 (1.81) | 5.56 (2.23–13.91) | 3 (0.77) | 2.35 (0.65–8.44) | 1 (0.48) | 1.45 (0.17–11.27) | 11 (0.33) |
| 7/4*0302 | 6 (2.15) | 0.87 (0.38–2.02) | 21 (4.74) | 1.97 (1.21–3.23) | 10 (2.56) | 1.05 (0.54–2.03) | 2 (0.95) | 0.38 (0.093–1.56) | 82 (2.46) |
| Y/4,*0302† | 15 (5.38) | 0.73 (0.43–1.24) | 31 (7.0) | 0.96 (0.65–1.42) | 43 (11.03) | 1.59 (1.13–2.23) | 27 (12.86) | 1.89 (1.24–2.89) | 242 (7.25) |
| 2,*0602/4,*0302 | 2 (0.72) | 0.30 (0.073–1.22) | 3 (0.68) | 0.28 (0.089–0.90) | 1 (0.26) | 0.11 (0.015–0.76) | 0 | –§ | 79 (2.37) |
| 2/4,*0302 | 1 (0.36) | 0.36 (0.049–2.65) | 3 (0.68) | 0.68 (0.021–2.24) | 4 (1.03) | 1.04 (0.37–2.95) | 1 (0.48) | 0.48 (0.065–3.52) | 33 (0.99) |
| 3/3 | 19 (6.81) | 5.47 (3.15–9.51) | 29 (6.55) | 5.25 (3.25–8.48) | 35 (8.97) | 7.38 (4.67–11.66 | 20 (9.52) | 7.88 (4.56–13.64) | 44 (1.32) |
| 3/1 | 8 (2.87) | 1.32 (0.63–2.77) | 16 (3.61) | 1.68 (0.97–2.91) | 16 (4.10) | 1.91 (1.1–3.32) | 5 (2.38) | 1.09 (0.44–2.73) | 73 (2.19) |
| 3/8 | 2 (0.72) | 0.78 (0.19–3.35) | 4 (0.90) | 1.01 (0.35–2.87) | 6 (1.54) | 1.72 (0.71–4.17) | 3 (1.43) | 1.60 (0.48–5.28) | 30 (0.90) |
| 3/9 | 6 (2.15) | 12.21 (3.91–38.11) | 3 (0.68) | 3.79 (0.94–15.20) | 1 (0.26) | 1.43 (0.17–11.89) | 1 (0.48) | 2.66 (0.32–22.18) | 6 (0.18) |
| 3/7 | 4 (1.43) | 0.55 (0.20–1.51) | 13 (2.93) | 1.14 (0.63–2.07) | 11 (2.82) | 1.10 (0.58–2.07) | 5 (2.38) | 0.92 (03.7–2.30) | 86 (2.58) |
| 3/Y† | 7 (2.51) | 0.45 (0.21–0.96) | 18 (4.06) | 0.73 (0.45–1.21) | 12 (3.08) | 0.55 (0.30–0.99) | 8 (3.81) | 0.69 (0.33–1.41) | 182 (5.45) |
| 3/2,*0602 | 1 (0.36) | 0.15 (0.020–1.04) | 2 (0.45) | 0.18 (0.45–0.75) | 1 (0.26) | 0.10 (0.014–0.75) | 3 (1.43) | 0.58 (0.18–1.86) | 81 (2.43) |
| 3/2 | 3 (1.08) | 1.33 (0.40–4.42) | 8 (1.81) | 2.26 (1.02–5.00) | 4 (1.03) | 1.27 (0.44–3.65) | 7 (3.33) | 4.23 (1.82–9.83) | 27 (0.81) |
| 3/4,*0301 | 6 (2.15) | 2.20 (0.91–5.30) | 10 (2.26) | 2.31 (1.13–4.73) | 9 (2.31) | 2.37 (1.12–4.98) | 5 (2.38) | 2.44 (0.94–6.33) | 33 (0.99) |
| 4/X,4/4,*0301‡ | 6 (2.15) | 0.24 (0.11–0.55) | 20 (4.51) | 0.52 (0.33–0.83) | 20 (5.13) | 0.60 (0.38–0.95) | 12 (5.71) | 0.67 (0.37–1.25) | 277 (8.30) |
| All others (X/X)‡ | 15 (5.38) | 0.052 (0.031–0.087) | 36 (8.13) | 0.080 (0.057–0.11) | 23 (5.91) | 0.057 (0.037–0.087) | 18 (8.57) | 0.085 (0.052–0.14) | 1750 (52.4) |
HLA, human leukocyte antigen.
†
Y = DR 10, 11, 12, 13, or 14.
‡
X = not DR3, not DR4.
§
Unable to calculate due to zero cell.