Table 2.
Group | EC Apoptosisa (%) | Villus height (μm) | Crypt depth (μm) |
---|---|---|---|
Non-operated Control | 1.6 ± 0.7 | 310 ± 42 | 93 ± 18 |
Sham | 2.7 ± 1.0 | 353 ± 40 | 77 ± 10 |
Sham+ACE-I | 1.9 ± 0.4† | 340 ± 20 | 87 ± 6 |
SBS | 4.3 ± 1.3* | 556 ± 66* | 113 ± 14* |
SBS+ACE-I | 1.8 ± 0.5‡ | 552 ± 56* | 145 ± 22‡ |
Summary (mean ±SD, from at least 6 mice per group) of results of ACE-inhibitor (ACE-I) studies. Sham+ACE-I was used as an additional control to assess the effects of ACE-I in the absence of a SBS.
Results of TUNEL analysis (number of apoptotic cells per 100 epithelial cells).
Abbreviations: IEL, intraepithelial lymphocytes; ACE-I angiotensin converting enzyme inhibitor; EC, epithelial cells.
P<0.05 sham vs. SBS
P<0.05 Sham vs. Sham + ACE-I
P<0.05 SBS vs. SBS+ACE-I.