5-HT	5-hydroxytryptamine
5-HT1A	5-hydroxytryptamine receptor 1A
5-HT2A	5-hydroxytryptamine receptor 2A
ABC	ATP-binding cassette
ABCB1	ATP-binding cassette subfamily B member 1
AKI	acute kidney injury
APAP	acetaminophen
ATF4	activating transcription factor 4
ATF6	activating transcription factor 6
ATP	adenosine triphosphate
AUCtau	area under the plasma concentration–time curve over a dosing interval
BBB	blood–brain barrier
cAMP	cyclic adenosine monophosphate
CBD	cannabidiol
CHOP	C/EBP homologous protein
CI	confidence interval
Cmax	maximum plasma concentration
CNS	central nervous system
COMT	catechol-O-methyltransferase
COX	cyclooxygenase
CYP	cytochrome P450
D2	dopamine D2 receptor
DDI	drug–drug interaction
ER	endoplasmic reticulum
EPS	extrapyramidal symptoms
GABA	gamma-aminobutyric acid
GABA-A	gamma-aminobutyric acid type A receptor
GFR	glomerular filtration rate
GI	gastrointestinal
GPCR	G protein-coupled receptor
Gq/11	Gq/11 family G protein
GSH	glutathione
hERG	human ether-à-go-go-related gene potassium channel
HLA	human leukocyte antigen
IKr	rapid delayed rectifier potassium current
IRE1α	inositol-requiring enzyme 1 alpha
JNK	c-Jun N-terminal kinase
KCNH2	potassium voltage-gated channel subfamily H member 2
MOR	μ-opioid receptor
NADPH	reduced nicotinamide adenine dinucleotide phosphate
NAPQI	N-acetyl-p-benzoquinone imine
NMDA	N-methyl-D-aspartate
NMS	neuroleptic malignant syndrome
NSAID	non-steroidal anti-inflammatory drug
OPRM1	opioid receptor mu 1
OR	odds ratio
PBPK	physiologically based pharmacokinetic
PERK	protein kinase R-like endoplasmic reticulum kinase
P-gp	P-glycoprotein
QSAR	quantitative structure–activity relationship
QTc	corrected QT interval
RCT	randomized controlled trial
RIDD	regulated IRE1-dependent decay
RNS	reactive nitrogen species
ROS	reactive oxygen species
SMILES	simplified molecular-input line-entry system
SNRI	serotonin–noradrenaline reuptake inhibitor
SSRI	selective serotonin reuptake inhibitor
TdP	torsades de pointes
THC	Δ9-tetrahydrocannabinol
UGT	UDP-glucuronosyltransferase
UGT2B7	UDP-glucuronosyltransferase 2B7
UPR	unfolded protein response
XBP1	X-box binding protein 1
ΔΨm	mitochondrial membrane potential