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Effect of CRH on adult dermal fibroblasts. A: In serum free conditions CRH significantly increased DNA synthesis (EC50 = 0.5 × 10-9 M) compared to untreated cells. B: Subsequent DNA content analysis yielded increase in transition of cells from G1/0 to S phase cell cycle compartment (see table below). Control: continuous line, CRH (100 nM): dashed line. *P < 0.05, **P < 0.005.
| Treatment | G1/0 [%] | S [%] | G2/M [%] |
|---|---|---|---|
| Control | 96±0.3 | 2±0.5 | 2±0.3 |
| CRH (100 nM) | 90±1 ** | 8±0.5 ** | 2±1 |
