786-O cells	human renal clear cell adenocarcinoma cells
BCA analysis	bicinchoninic acid assay
BP	biological process
BSA	bovine serum albumin
CC	cellular component
CCK-8	cell counting kit-8
ccRCC	clear cell renal cell carcinoma
CD8	cluster of differentiation 8
CD31	platelet endothelial cell adhesion molecule-1
COX-2	cyclooxygenase-2
FBS	fetal bovine serum
FDR	false-discovery rate
FEL	free-energy landscape
GO	gene ontology
HIF	hypoxia-inducible factor
HIF-1α	hypoxia-inducible factor 1-alpha
HIF-2α	hypoxia-inducible factor 2-alpha
H&E	hematoxylin and eosin
IC50	half-maximal inhibitory concentration
IF	immunofluorescence
IHC	immunohistochemistry
Kansui-DCM	the dichloromethane fraction of Kansui Radix
KEGG	Kyoto Encyclopedia of Genes and Genomes
Ki67	Kiel 67
MF	molecular function
MM/PBSA	molecular mechanics/Poisson–Boltzmann surface area
PBS	phosphate-buffered saline
PVDF	polyvinylidene fluoride
PDB	Protein Data Bank
qRT-PCR	quantitative reverse-transcription polymerase chain reaction
RCC	renal cell carcinoma
RENCA cells	mouse renal carcinoma
RESP	restrained electrostatic potential
Rg	radius of gyration
RIPA	radioimmunoprecipitation assay
RMSD	root-mean-square deviation
RMSF	root-mean-square fluctuation
SASA	solvent-accessible surface area
SDS-PAGE	sodium dodecyl sulfate-polyacrylamide gel electrophoresis
TBST	Tris-buffered saline with Tween-20
UPLC-MS	ultra-high-performance liquid chromatography–mass spectrometry
VEGF	vascular endothelial growth factor
VEGFA	vascular endothelial growth factor A
VEGFR2	vascular endothelial growth factor receptor 2
VHL	von hippel–lindau tumor suppressor
WB	Western blot
WGCNA	weighted gene co-expression network analysis