ACSL4	acyl-CoA synthetase long-chain family member 4
ALT	alanine aminotransferase
AMPK	AMP-activated protein kinase
APC	antigen-presenting cell
AST	aspartate aminotransferase
AUC	area under the concentration-time curve
BA	bioavailability
BAX	BCL2-associated X protein
BCL2	B-cell lymphoma 2
BCS	Biopharmaceutics Classification System
CD206	mannose receptor
CNS	central nervous system
Cmax	maximum plasma concentration
EC50	half-maximal effective concentration
EPGLa	G. lucidum polysaccharide a
EPR	enhanced permeability and retention
GAA	ganoderic acid A
GAB	ganoderic acid B
GAC1	ganoderic acid C1
GAC2	ganoderic acid C2
GAD	ganoderic acid D
GAF	ganoderic acid F
GAG	ganoderic acid G
GAH	ganoderic acid H
GAK	ganoderic acid K
GALT	gut-associated lymphoid tissue
GA-NPs	ganoderic acid-loaded nanoparticles
GA-SLNs	ganoderic acid-loaded solid lipid nanoparticles
GL-AgNPs	G. lucidum-mediated silver nanoparticles
GLNs	G. lucidum-derived nanovesicles
GLP	G. lucidum polysaccharide
GLP-LNPs	GLP-loaded lipid nanoparticles
GLP-LU-TeNRs	GLP-based multifunctional tellurium nanorods
GLP-MTX	GLP-methotrexate conjugate
GLP-SeNPs	GLP-stabilized selenium nanoparticles
GMP	Good Manufacturing Practice
GSH-GPX4	glutathione-glutathione peroxidase 4
HO-1	heme oxygenase-1
HPLC	high-performance liquid chromatography
HWE	hot water extraction
IL-6	interleukin-6
JAK/STAT	Janus kinase/signal transducer and activator of transcription
LC-MS/MS	liquid chromatography-tandem mass spectrometry
LNP	lipid nanoparticle
MAE	microwave-assisted extraction
MAFLD	metabolic-associated fatty liver disease
MAPK	mitogen-activated protein kinase
MN-WSG	dissolvable microneedle patch loaded with water-soluble glucan
mRNA	messenger RNA
Mw	molecular weight
NF-κB	nuclear factor kappa-B
NLC	nanostructured lipid carrier
NO	nitric oxide
NP	nanoparticle
NRF2	nuclear factor erythroid 2-related factor 2
PK	pharmacokinetic
PLGA	poly(lactic-co-glycolic acid)
PNP	polymeric nanoparticle
RCT	randomized controlled trial
ROS	reactive oxygen species
SAF	structure–activity–formulation
SCE	supercritical CO2 extraction
SeNP	selenium nanoparticle
SLN	solid lipid nanoparticle
SOD	superoxide dismutase
t1/2	elimination half-life
TeNR	tellurium nanorod
TLR4	Toll-like receptor 4
Tmax	time to maximum plasma concentration
TNF-α	tumor necrosis factor-alpha
UAE	ultrasonic-assisted extraction
UMAE	ultrasonic-microwave-assisted extraction
UPLC-Q-TOF/MS	ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry
WSG	water-soluble glucan
XRCC1	X-ray repair cross-complementing protein 1